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| Research article summary (published 6 Jun 2009): |
Functional differentiation and cooperation among the hippocampal subregions in rats to effect spatial memory processes.
Full Abstract
We investigated the roles of the hippocampal subregions and intrahippocampal networks in effecting spatial reference and working processes. The results showed that the dentate gyrus plays a key role in encoding both types of spatial memory. Lesions in the dentate gyrus caused severe impairment in the acquisition of the Morris water maze and delayed matching-to-place tasks as compared to those in the other hippocampal subregions (Exp. 1). Further, there was functional cooperation between CA3 and CA1 via the Schaffer collaterals and the hippocampal commissure in the performance of both types of spatial memory tasks. Among the rats with intact hippocampal commissure, those with both contralateral and ipsilateral CA1/CA3 lesions showed a similar performance (Exp. 2A); however, among the rats with transected hippocampal commissure, those with the contralateral CA1/CA3 lesions showed a more disruptive performance than the rats with the ipsilateral CA1/CA3 lesions (Exp. 2B). This study suggests that the hippocampus is the functional unit for spatial reference and working memory processes, including differential functions and functional cooperation among the hippocampal subregions.
Author information
Author/s: Okada, Kana (K); Okaichi, Hiroshige (H);
Affiliation: Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University, Japan. kokada(-atsign-)fmu.ac.jp
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)
Reference: 2009-Jun; vol 200 (issue 1) : pp 181-91
Dates: Created 2009/04/17; Completed 2009/06/18;
PMID: 19378463, status: MEDLINE (last retrieval date: 6/18/2009, IMS Date: 18 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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