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| Research article summary (published 30 Dec 2008): |
[Protective effects of AST and ASI on memory impairment and its mechanism in senescent rats treated by GC]
Full Abstract
OBJECTIVE: To study the protective effects and mechanisms of astragaloside (AST) and astragalus saponin I (ASI) on the memory impairment in senescent rats treated by glucocorticoid (GC). METHOD: Y maze test was performed to determine the effects of AST and ASI on memory impairment of hydrocortisone(HC)-induced senescent rats. Using Ca2+ sensitive fluorescent indicator (Furo-2), free intracellular calcium concentration ([Ca2+]i) was measured by double wavelength fluorescence sepectrophotometer in thymocytes and hippocampal neurons induced dexamethasone (DEX). And apoptosis was detected by DNA gel electrophoresis and flow cytometry. RESULT: Compared with HC control, AST and ASI can improve the memory of the senescent rats treated by HC, lower [Ca2+]i and suppress apoptosis of thymocytes and hippocampal neurons induced by DEX. CONCLUSION: AST and ASI can delay the aging in rats treated by HC, and its mechanism may includ lowering[Ca2+]i and suppressing the apoptosis of thymocytes and hippocampal neurons.
Author information
Author/s: Li, Weizu (W); Li, Weiping (W); Yin, Yanyan (Y); Gong, Huiling (H); Wu, Guocui (G); Zhu, Fenfang (F);
Affiliation: Department of Pharmacology, Anhui Medical University, Hefei 230032, China.
Journal and publication information
Publication Type: English Abstract; Journal Article
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi), published in China. (Language: chi)
Reference: 2009-Jan; vol 34 (issue 2) : pp 199-203
Dates: Created 2009/04/23; Completed 2009/06/01;
PMID: 19385186, status: MEDLINE (last retrieved date: 6/1/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Glucocorticoids (0) ; Saponins (0) ; Dexamethasone (50-02-2) ; Calcium (7440-70-2)Related articles
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