Research article summary (published 30 Aug 2009):

Establishing a relationship between activity reduction in human perirhinal cortex and priming.

Full Abstract

Perirhinal neurons exhibit reduced firing rates with stimulus repetition, a phenomenon termed "repetition suppression." However, relationships between perirhinal repetition suppression and behavioral expressions of memory remain unclear. We used anatomically constrained functional magnetic resonance imaging (fMRI) to assess relationships between perirhinal activity and priming, a type of implicit memory. Priming was expressed as speeded animacy judgments for old versus new words. Concurrently, old words elicited less neural activity in bilateral perirhinal cortex. The magnitude of the left perirhinal activity reduction selectively predicted the magnitude of behavioral priming in an across-subjects hierarchical linear regression analysis. These findings have implications for considering how perirhinal cortex may contribute to different neurocognitive functions, possibly including both implicit memory and familiarity-based recognition. This study documents the first evidence linking behavioral measures of priming to information processing in perirhinal cortex. (c) 2009 Wiley-Liss, Inc.

Author information

Author/s: Voss, Joel L (JL); Hauner, Katherina K Y (KK); Paller, Ken A (KA);

Affiliation: Department of Psychology, Northwestern University, Evanston, Illinois, USA. joelvoss(-atsign-)illinois.edu

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Hippocampus (Hippocampus), published in United States. (Language: eng)

Reference: 2009-Sep; vol 19 (issue 9) : pp 773-8

Dates: Created 2009/09/01; Completed 2009/10/30;

PMID: 19405122, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance Entorhinal Cortex - physiology Functional Laterality Hippocampus - physiology Humans Judgment - physiology Magnetic Resonance Imaging

Magnetic Resonance Imaging Memory - physiology Mental Processes - physiology Neuropsychological Tests Reaction Time Regression Analysis Temporal Lobe - physiology

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