Research article summary (published 29 Sep 2009):

Failure rate of contemporary low-dose radiosurgical technique for vestibular schwannoma.

Full Abstract

OBJECT: The decline in cranial nerve morbidity after radiosurgery for vestibular schwannoma (VS) correlates with dose reduction and other technical changes to this procedure. The effect these changes have had on tumor control has not been well documented. METHODS: The authors performed a retrospective review of 293 patients with VSs who underwent radiosurgery between 1990 and 2004 and had a minimum of 24 months of imaging follow-up (90% of the entire series). The median radiation dose to the tumor margin was 13 Gy. Treatment failure was defined as progressive tumor enlargement noted on 2 or more imaging studies. The mean postradiosurgical follow-up was 60.9 +/- 32.5 months. RESULTS: Tumor growth was noted in 15 patients (5%) at a median of 32 months after radiosurgery. Radiographically demonstrated tumor control was 96% at 3 years and 94% at 7 years after radiosurgery. Univariate analysis revealed 2 factors that correlated with failed radiosurgery for VS: an increasing number of isocenters (p = 0.03) and tumor margin radiation doses

Author information

Author/s: Pollock, Bruce E (BE); Link, Michael J (MJ); Foote, Robert L (RL);

Affiliation: Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. pollock.bruce(-atsign-)mayo.edu

Journal and publication information

Publication Type: Journal Article

Journal: Journal of neurosurgery (J Neurosurg), published in United States. (Language: eng)

Reference: 2009-Oct; vol 111 (issue 4) : pp 840-4

Dates: Created 2009/10/02; Completed 2009/10/23;

PMID: 19408975, status: MEDLINE (last retrieval date: 10/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aged Female Follow-Up Studies Humans Male Middle Aged

Multivariate Analysis Neuroma, Acoustic - surgery Radiation Dosage Radiosurgery - methods Recurrence Retrospective Studies Treatment Failure

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