Predictive feedback can account for biphasic responses in the lateral geniculate nucleus.

Full Abstract

Biphasic neural response properties, where the optimal stimulus for driving a neural response changes from one stimulus pattern to the opposite stimulus pattern over short periods of time, have been described in several visual areas, including lateral geniculate nucleus (LGN), primary visual cortex (V1), and middle temporal area (MT). We describe a hierarchical model of predictive coding and simulations that capture these temporal variations in neuronal response properties. We focus on the LGN-V1 circuit and find that after training on natural images the model exhibits the brain's LGN-V1 connectivity structure, in which the structure of V1 receptive fields is linked to the spatial alignment and properties of center-surround cells in the LGN. In addition, the spatio-temporal response profile of LGN model neurons is biphasic in structure, resembling the biphasic response structure of neurons in cat LGN. Moreover, the model displays a specific pattern of influence of feedback, where LGN receptive fields that are aligned over a simple cell receptive field zone of the same polarity decrease their responses while neurons of opposite polarity increase their responses with feedback. This phase-reversed pattern of influence was recently observed in neurophysiology. These results corroborate the idea that predictive feedback is a general coding strategy in the brain.

Author information

Author/s: Jehee, Janneke F M (JF); Ballard, Dana H (DH);

Affiliation: Center for Visual Science and Department of Computer Science, University of Rochester, Rochester, NY, USA. janneke.jehee(-atsign-)vanderbilt.edu

Grants: EY05729 (Agency:NEI NIH HHS) ; R01 RR009283 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: PLoS computational biology (PLoS Comput Biol), published in United States. (Language: eng)

Reference: 2009-May; vol 5 (issue 5) : pp e1000373

Dates: Created 2009/05/04; Completed 2009/06/24;

PMID: 19412529, status: MEDLINE (last retrieval date: 6/24/2009, IMS Date: 24 Jun 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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