Too many ends: aberrant transposition.

Full Abstract

A recent study by Zhang and colleagues published in the March 15, 2009, issue of Genes & Development (pp. 755-765) demonstrates that maize Ac/Ds transposons mediate translocations and other rearrangements through aberrant execution of the normal transposition process. Ac transposase uses one end from each of two neighboring elements in these events, which may happen more commonly than previously thought. In genomes where there can be many transposon ends scattered across all the chromosomes, such mistakes can have important consequences.

Author information

Author/s: Weil, Clifford F (CF);

Affiliation: Agronomy Department, Purdue University, West Lafayette, Indiana 47907, USA. cweil(-atsign-)purdue.edu

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Genes & development (Genes Dev), published in United States. (Language: eng)

Reference: 2009-May; vol 23 (issue 9) : pp 1032-6

Dates: Created 2009/05/06; Completed 2009/05/08;

PMID: 19417101, status: MEDLINE (last retrieved date: 5/8/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals
DNA Transposable Elements - genetics
Gene Rearrangement - genetics

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: DNA Transposable Elements (0) ; Transposases (EC 2.7.7.-)

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