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| Research article summary (published 4 May 2009): |
Frontoparietal cortex controls spatial attention through modulation of anticipatory alpha rhythms.
Full Abstract
A dorsal frontoparietal network, including regions in intraparietal sulcus (IPS) and frontal eye field (FEF), has been hypothesized to control the allocation of spatial attention to environmental stimuli. One putative mechanism of control is the desynchronization of electroencephalography (EEG) alpha rhythms (approximately 8-12 Hz) in visual cortex in anticipation of a visual target. We show that brief interference by repetitive transcranial magnetic stimulation (rTMS) with preparatory activity in right IPS or right FEF while subjects attend to a spatial location impairs identification of target visual stimuli approximately 2 s later. This behavioral effect is associated with the disruption of anticipatory (prestimulus) alpha desynchronization and its spatially selective topography in parieto-occipital cortex. Finally, the disruption of anticipatory alpha rhythms in occipital cortex after right IPS- or right FEF-rTMS correlates with deficits of visual identification. These results support the causal role of the dorsal frontoparietal network in the control of visuospatial attention, and suggest that this is partly exerted through the synchronization of occipital visual neurons.
Author information
Author/s: Capotosto, Paolo (P); Babiloni, Claudio (C); Romani, Gian Luca (GL); Corbetta, Maurizio (M);
Affiliation: Dipartimento di Scienze Cliniche e Bioimmagini and Istituto di Tecnologie Avanzate Biomediche Università G. D'Annunzio, 66013 Chieti, Italy.
Grants: R01 MH071920-06 (Agency:NIMH NIH HHS) ; R01 MH71920-06 (Agency:NIMH NIH HHS) ; R01 NS048013-04 (Agency:NINDS NIH HHS) ; R01 NS48013 (Agency:NINDS NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2009-May; vol 29 (issue 18) : pp 5863-72
Dates: Created 2009/05/07; Completed 2009/05/28; Revised 2009/11/09;
PMID: 19420253, status: MEDLINE (last retrieval date: 11/10/2009, IMS Date: 10 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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