Research article summary (published 5 May 2009):

Active middle-aged men have lower fasting inflammatory markers but the postprandial inflammatory response is minimal and unaffected by physical activity status.

Full Abstract

Physical activity modifies some postprandial responses such as glycemic control, although it is unclear whether this translates into lower postprandial inflammation. Our objective in this study was to determine whether postprandial inflammatory markers are lower in active compared with sedentary middle-aged men. Thirteen active and twelve sedentary middle-aged men consumed a mixed meal on one occasion. Blood was taken via a cannula before and up to 8 h after the meal and with a single-use needle before and 8 h after the meal. Active men had lower fasted IL-6 (0.6 +/- 0.2 vs. 1.2 +/- 0.3 pg/ml; P = 0.004) and C-reactive protein (1.3 +/- 0.3 vs. 2.9 +/- 0.6 mg/l; P = 0.04) concentrations than sedentary men. Cannula blood IL-6 concentrations increased by 3.49 pg/ml in the 8 h following the meal (P < 0.001); however, this increase was minimal (0.36 pg/ml) in blood taken via a single-use needle from the contralateral arm (P = 0.013). The sedentary group had larger glucose (P = 0.034), insulin (P = 0.013), and triacylglycerol (P = 0.057) responses to the meal. These results provide further evidence that physical activity is associated with lower inflammatory marker concentrations in a fasted state and a lower postprandial metabolic response to a meal. However, this does not translate into lower postprandial inflammatory markers since the only evidence of postprandial inflammation (a large increase in serum IL-6) was actually due to the cannula used for blood sampling.

Author information

Author/s: Dixon, Natalie C (NC); Hurst, Tina L (TL); Talbot, Duncan C S (DC); Tyrrell, Rex M (RM); Thompson, Dylan (D);

Affiliation: Sport and Exercise Science, School for Health, Univ. of Bath, Bath, United Kingdom BA2 7AY.

Grants: (Agency:Biotechnology and Biological Sciences Research Council)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of applied physiology (Bethesda, Md. : 1985) (J Appl Physiol), published in United States. (Language: eng)

Reference: 2009-Jul; vol 107 (issue 1) : pp 63-8

Dates: Created 2009/07/01; Completed 2009/08/28;

PMID: 19423836, status: MEDLINE (last retrieved date: 8/28/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Biological Markers - metabolism Blood Glucose - analysis C-Reactive Protein - metabolism Exercise - physiology Food Deprivation - physiology Humans Insulin - blood

Insulin - blood Interleukin-6 - blood Male Middle Aged Motor Activity - physiology Postprandial Period - physiology Triglycerides - blood

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Biological Markers (0) ; Blood Glucose (0) ; IL6 protein, human (0) ; Interleukin-6 (0) ; Triglycerides (0) ; Insulin (11061-68-0) ; C-Reactive Protein (9007-41-4)

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