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| Research article summary (published 30 May 2009): |
Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors.
Full Abstract
The purpose of the present study was to identify genetic variants which confer susceptibility to chronic kidney disease (CKD) in high- or low-risk subjects defined by conventional risk factors separately. The study population comprised 2828 Japanese individuals, including 434 subjects with CKD [estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2)] and 2394 controls (eGFR > or =60 ml/min/ 1.73 m(2)). The 1012 high-risk subjects had both hypertension and diabetes mellitus, and the 1816 low-risk subjects had none of these conditions. The genotypes for 296 polymorphisms of 202 candidate genes were determined. The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, as well as a stepwise forward selection procedure revealed that ten different polymorphisms were associated (P<0.05) with the prevalence of CKD in high- or low-risk subjects: the -519Aright curved arrow G polymorphism of MMP1, the 1061Aright curved arrow G (Ile405Val) polymorphism of CETP, the Aright curved arrow G (Lys45Glu) polymorphism of MMP3, the -219Gright curved arrow T polymorphism of APOE, the Aright curved arrow G (Ile1205Val) polymorphism of COL3A1, the -863Cright curved arrow A polymorphism of TNF, and the 1454Cright curved arrow G (Leu125Val) polymorphism of PECAM1 in high-risk subjects; and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2, the 2386Aright curved arrow G (Ile796Val) polymorphism of SCAP, and the TAAAright curved arrow del polymorphism of PDE4D in low-risk subjects. Among these polymorphisms, the -519Aright curved arrow G polymorphism of MMP1 and the 1167Cright curved arrow T (Asn389Asn) polymorphism of TGFBR2 were most significantly associated with CKD in high- or low-risk individuals, respectively. These results suggest that polymorphisms associated with CKD may differ among high- or low-risk subjects. Stratification of subjects according to conventional risk factors may thus be important for personalized prevention of CKD based on genetic information.
Author information
Author/s: Yoshida, Tetsuro (T); Kato, Kimihiko (K); Yokoi, Kiyoshi (K); Oguri, Mitsutoshi (M); Watanabe, Sachiro (S); Metoki, Norifumi (N); Yoshida, Hidemi (H); Satoh, Kei (K); Aoyagi, Yukitoshi (Y); Nishigaki, Yutaka (Y); Nozawa, Yoshinori (Y); Yamada, Yoshiji (Y);
Affiliation: Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: International journal of molecular medicine (Int J Mol Med), published in Greece. (Language: eng)
Reference: 2009-Jun; vol 23 (issue 6) : pp 785-92
Dates: Created 2009/05/08; Completed 2009/07/30;
PMID: 19424605, status: MEDLINE (last retrieval date: 8/20/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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