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| Research article summary (published 18 Feb 2009): |
Trichotillomania: neurobiology and treatment.
Full Abstract
Trichotillomania is a disorder characterized by repetitive hair pulling, leading to noticeable hair loss and functional impairment. This paper provides an overview of what is known of trichotillomania from several perspectives. We begin by considering historical descriptions of hair pulling that ultimately contributed to the inclusion of trichotillomania as a formal diagnostic entity in the Diagnostic and Statistical Manual. Psychological factors involved in the mediation of symptoms are examined, including positive and negative reinforcement. The relationships between trichotillomania, other body-focused repetitive behaviours, and disorders of the putative obsessive-compulsive (OC) spectrum are surveyed. The review then explores findings from the available controlled treatment trials that utilized psychotherapy, pharmacotherapy, or both. Neural circuitry involved in the manifestation of hair pulling is then identified by considering data from animal models of the condition, along with neurocognitive and neuroimaging results from patients. Finally, we highlight important areas for future neurobiological and treatment research.
Author information
Author/s: Chamberlain, Samuel R (SR); Odlaug, Brian L (BL); Boulougouris, Vasileios (V); Fineberg, Naomi A (NA); Grant, Jon E (JE);
Affiliation: Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. srchamb(-atsign-)gmail.com
Grants: K23 MH069754-01A1 (Agency:NIMH NIH HHS) ; (Agency:Medical Research Council) ; (Agency:Wellcome Trust)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Journal: Neuroscience and biobehavioral reviews (Neurosci Biobehav Rev), published in United States. (Language: eng)
Reference: 2009-Jun; vol 33 (issue 6) : pp 831-42
Dates: Created 2009/05/11; Completed 2009/06/22;
PMID: 19428495, status: MEDLINE (last retrieval date: 6/22/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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