Research article summary (published 10 May 2009):

Sexual function in adult male rats after prenatal modulation of the cholinergic system.

Full Abstract

Prenatal administration of the n-cholinolytic ganglerone to pregnant female rats at different periods of gestation was found to lead to long-term changes in sexual behavior in pubescent offspring: there was a reduced dynamic of acquiring sexual experience and a very low level of sexual activity, with significant impairment to the motivational and ejaculatory components of sexual behavior. The number of males with reduced sexual activity in the experimental groups was significantly greater than that in control offspring. The results obtained here provide evidence that impairments of sexual function in adult offspring induced by prenatal administration of the n-cholinolytic ganglerone at 9-11 and 12-14 days of gestation and, to a lesser extent, the m-cholinolytic metamyzil at 9-11 days of gestation, were due to impairment to the central mechanisms regulating sexual function due to stable changes in neurotransmitter activity in the hippocampus and hypothalamus, along with a significant reduction in the blood testosterone level.

Author information

Author/s: Bairamov, A A (AA); Poletaeva, A O (AO); Proshin, S N (SN); Efremov, O M (OM); Sapronov, N S (NS);

Affiliation: I. P. Pavlov St. Petersburg State Medical University, 6/8 L. Tolstoy Square, 197022, St. Petersburg, Russia. alekber(-atsign-)mail.ru

Journal and publication information

Publication Type: Journal Article

Journal: Neuroscience and behavioral physiology (Neurosci Behav Physiol), published in United States. (Language: eng)

Reference: 2009-Jun; vol 39 (issue 5) : pp 463-70

Dates: Created 2009/05/18; Completed 2009/08/18;

PMID: 19430975, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Benactyzine - adverse effects; analogs & derivatives; pharmacology Benzoates - adverse effects; pharmacology Female Gestational Age Limbic System - metabolism; pathology; physiopathology Male

Parasympatholytics - adverse effects; pharmacology Pregnancy Prenatal Exposure Delayed Effects - blood; pathology; physiopathology Rats Rats, Wistar Sexual Behavior, Animal - drug effects Testosterone - blood

Associated Chemicals: Benzoates (0) ; Parasympatholytics (0) ; ganglerone (299-61-6) ; Benactyzine (302-40-9) ; metamizil (57-36-3) ; Testosterone (58-22-0)

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