Research article summary (published 7 May 2009):

Prenatal lead exposure enhances methamphetamine sensitization in rats.

Full Abstract

Adult female rats were exposed to lead-free sodium acetate via gavage [0 mg (vehicle control)] or to 16 mg lead as lead acetate for 30 days prior to breeding. Following confirmation of breeding, the female animals continued to be exposed to their respective doses throughout gestation and lactation. When weaned, 16 control and 16 lead-exposed offspring were placed on regular water and food (lead-exposure was discontinued) until postnatal day (PND) 70. At this time, one-half of the control animals and one-half of the lead-treatment animals received intraperitoneal (i.p.) injections of the vehicle (saline) for 10 successive days and the remaining animals in each exposure conditions received daily injections of 1.0 mg/kg (+)-methamphetamine (METH) for 10 days (N=8/group). Locomotion in automated chambers was monitored daily for 45 min post-injection. Subsequently, during dose-effect testing, all animals received consecutive daily i.p. injections of 0, 1.0, 2.0, and then 4.0 mg/kg METH. The results of the experiment showed that both control and lead-exposed animals exhibited heightened locomotor activity (i.e. behavioral sensitization) to the repeated administration of 1.0 mg/kg METH. More importantly, animals developmentally (perinatally) exposed to lead showed more rapid sensitization than did their control counterparts. These data indicate that early lead exposure increases sensitivity to the locomotor-stimulating effects of METH. In contrast, identically exposed lead animals exhibit diminished METH dose-effect responding when tested in an intravenous (i.v.) self-administration paradigm [Rocha A., Valles R., Bratton G.R., Nation J.R. Developmental lead exposure alters methamphetamine self-administration in the male rat: acquisition and reinstatement. Drug Alcohol Depend 2008a;95:23-29, Rocha A., Valles R., Hart N., Bratton G.R., Nation J.R. Developmental lead exposure attenuates methamphetamine dose-effect self-administration performance and progressive ratio responding in the male rat. Pharmacol Biochem Behav 2008b;89:508-514].

Author information

Author/s: Clifford, P Shane (PS); Hart, Nigel (N); Thompson, Jeff (J); Buckman, Sam (S); Wellman, Paul J (PJ); Bratton, Gerald R (GR); Nation, Jack R (JR);

Affiliation: Department of Psychology, Texas A&M University, College Station, TX 77843, USA.

Grants: DA13188 (Agency:NIDA NIH HHS) ; MH65728 (Agency:NIMH NIH HHS) ; R01 DA013188-05 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav), published in United States. (Language: eng)

Reference: 2009-Aug; vol 93 (issue 2) : pp 165-9

Dates: Created 2009/06/15; Completed 2009/08/28; Revised 2009/10/29;

PMID: 19433104, status: MEDLINE (last retrieval date: 10/30/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amphetamine-Related Disorders - psychology Animals Body Weight - drug effects Central Nervous System Stimulants - pharmacokinetics; pharmacology Dose-Response Relationship, Drug Female Injections, Intraperitoneal Injections, Intravenous Lead - blood; pharmacokinetics Lead Poisoning, Nervous System - psychology

Lead Poisoning, Nervous System - psychology Male Methamphetamine - pharmacokinetics; pharmacology Motor Activity - drug effects Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Self Administration Stereotyped Behavior - drug effects

Associated Chemicals: Central Nervous System Stimulants (0) ; Methamphetamine (537-46-2) ; Lead (7439-92-1)

Related articles

These are the highest related articles currently in the database:

• Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. 30 Oct 2006
• Sex differences in (+)-amphetamine- and (+)-methamphetamine-induced behavioral response in male and female Sprague-Dawley rats. 7 Jan 2007
• Chronic methamphetamine increases fighting in mice. 30 Jan 2004
• A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior. 15 Sep 2007
• Spontaneous locomotor activity and pharmacokinetics of intravenous methamphetamine and its metabolite amphetamine in the rat. 29 Nov 1999
• Human pharmacology of the methamphetamine stereoisomers. 29 Sep 2006
• Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine. 15 Oct 2003
• Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration. 16 Jan 2006
• Sensitization and cross-sensitization after chronic treatment with methylphenidate in adolescent Wistar rats. 29 Apr 2007
• Pharmacodynamic mechanisms of monoclonal antibody-based antagonism of (+)-methamphetamine in rats. 12 Feb 2003

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.