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| Research article summary (published 29 Apr 2009): |
Early age-related macular degeneration, cognitive function, and dementia: the Cardiovascular Health Study.
Full Abstract
OBJECTIVE: To describe the association of cognitive function and dementia with early age-related macular degeneration (AMD) in older individuals. METHODS: This population-based study included 2,088 persons aged 69 to 97 years who participated in the Cardiovascular Health Study. The AMD was assessed from retinal photographs based on a modified Wisconsin AMD grading system. Cognitive function was assessed using the Digit Symbol Substitution Test (DSST) and the Modified Mini-Mental State Examination. Participants were also evaluated for dementia using detailed neuropsychological testing. RESULTS: After controlling for age, sex, race, and study center, persons with low DSST scores (lowest quartile of scores, < or =30) were more likely to have early AMD (odds ratio, 1.38; 95% confidence interval, 1.03-1.85) than were persons with higher DSST scores. In analyses further controlling for education, systolic blood pressure, total cholesterol level, diabetes mellitus, smoking status, and apolipoprotein E genotype, this association was stronger (odds ratio, 2.00; 95% confidence interval, 1.29-3.10). There was no association of low Modified Mini-Mental State Examination scores, dementia, or Alzheimer disease with early AMD. CONCLUSIONS: In this older population, cognitive impairment may share common age-related pathogenesis and risk factors with early AMD.
Author information
Author/s: Baker, Michelle L (ML); Wang, Jie Jin (JJ); Rogers, Sophie (S); Klein, Ronald (R); Kuller, Lewis H (LH); Larsen, Emily K (EK); Wong, Tien Yin (TY);
Affiliation: Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia.
Grants: N01 HC-15103 (Agency:NHLBI NIH HHS) ; N01 HC-55222 (Agency:NHLBI NIH HHS) ; N01-HC-35129 (Agency:NHLBI NIH HHS) ; N01-HC-45133 (Agency:NHLBI NIH HHS) ; N01-HC-75150 (Agency:NHLBI NIH HHS) ; N01-HC-85079 (Agency:NHLBI NIH HHS) ; N01-HC-85086 (Agency:NHLBI NIH HHS) ; R21-HL077166 (Agency:NHLBI NIH HHS) ; U01 HL080295 (Agency:NHLBI NIH HHS)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal: Archives of ophthalmology (Arch Ophthalmol), published in United States. (Language: eng)
Reference: 2009-May; vol 127 (issue 5) : pp 667-73
Dates: Created 2009/05/12; Completed 2009/05/22;
PMID: 19433718, status: MEDLINE (last retrieval date: 5/22/2009, IMS Date: 22 May 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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