Addiction memory as a specific, individually learned memory imprint.

Full Abstract

The construct of "addiction memory" (AM) and its importance for relapse occurrence has been the subject of discussion for the past 30 years. Neurobiological findings from "social neuroscience" and biopsychological learning theory, in conjunction with construct-valid behavioral pharmacological animal models, can now also provide general confirmation of addiction memory as a pathomorphological correlate of addiction disorders. Under multifactorial influences, experience-driven neuronal learning and memory processes of emotional and cognitive processing patterns in the specific individual "set" and "setting" play an especially pivotal role in this connection. From a neuropsychological perspective, the episodic (biographical) memory, located at the highest hierarchical level, is of central importance for the formation of the AM in certain structural and functional areas of the brain and neuronal networks. Within this context, neuronal learning and conditioning processes take place more or less unconsciously and automatically in the preceding long-term-memory systems (in particular priming and perceptual memory). They then regulate the individually programmed addiction behavior implicitly and thus subsequently stand for facilitated recollection of corresponding, previously stored cues or context situations. This explains why it is so difficult to treat an addiction memory, which is embedded above all in the episodic memory, from the molecular carrier level via the neuronal pattern level through to the psychological meaning level, and has thus meanwhile become a component of personality.

Author information

Author/s: Böning, J (J);

Affiliation: Clinic for Psychiatry, Psychosomatic Medicine and Psychotherapy, University of Würzburg, Würzburg, Germany. jobst.boening(-atsign-)gmx.net

Journal and publication information

Publication Type: Journal Article; Review

Journal: Pharmacopsychiatry (Pharmacopsychiatry), published in Germany. (Language: eng)

Reference: 2009-May; vol 42 Suppl 1 (issue ) : pp S66-8

Dates: Created 2009/05/12; Completed 2009/07/01;

PMID: 19434557, status: MEDLINE (last retrieval date: 7/1/2009, IMS Date: 01 Jul 2009 00:00:00)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Behavior, Addictive - etiology; physiopathology
Brain - physiopathology
Disease Models, Animal

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