Research article summary (published 12 May 2009):

Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific.

Full Abstract

The aim of our study was to reveal whether acute methamphetamine (MA) administration changes the sensitivity to seizures induced by N-methyl-D-aspartate (NMDA) in prenatally MA-exposed adult rats. Adult rats with respect to sex and female estrous cycle (prenatally MA-exposed, prenatally saline-exposed, and controls) were divided into groups with acute MA (1 mg/kg) or without acute drug administration (saline injection). Intraperitoneal administration of 250 mg/kg of NMDA was used as a seizure model. The present study demonstrated that both prenatal MA and prenatal saline exposure decreased the latency to onset of stereotypy and clonic-tonic seizures. Acute MA administration decreased latency to onset of stereotypic behavior in all groups, while increased latency to onset of clonic-tonic seizures in prenatally saline-exposed rats. The duration of NMDA seizures was longer after acute MA administration relative to animals without acute MA pretreatment in both control groups. In addition, males displayed decreased susceptibility to NMDA-induced seizures relative to females regardless of their estrous cycle. Our study suggests that acute MA exposure changes susceptibility to NMDA-induced seizures in respect of prenatal exposure and sex. However, it seems that the effect of prenatal exposure is not induced by the drug per se but rather by the repeated injection exposure that causes prenatal stress.

Author information

Author/s: Slamberová, Romana (R); Schutová, Barbora (B); Matejovská, Iveta (I); Bernásková, Klára (K); Rokyta, Richard (R);

Affiliation: Department of Normal, Pathological and Clinical Physiology, Third Faculty of Medicine, Charles University in Prague, Praha 2, Prague, Czech Republic. rslamber(-atsign-)lf3.cuni.cz

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Naunyn-Schmiedeberg's archives of pharmacology (Naunyn Schmiedebergs Arch Pharmacol), published in Germany. (Language: eng)

Reference: 2009-Aug; vol 380 (issue 2) : pp 109-14

Dates: Created 2009/06/11; Completed 2009/08/19;

PMID: 19440696, status: MEDLINE (last retrieved date: 8/21/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Central Nervous System Stimulants - pharmacology Drug Administration Schedule Estrous Cycle - physiology Excitatory Amino Acid Agonists - administration & dosage; toxicity Female Male Methamphetamine - pharmacology N-Methylaspartate - administration & dosage; toxicity

N-Methylaspartate - administration & dosage; toxicity Pregnancy Prenatal Exposure Delayed Effects Rats Rats, Wistar Seizures - chemically induced Sex Factors Stereotyped Behavior - drug effects Time Factors

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Central Nervous System Stimulants (0) ; Excitatory Amino Acid Agonists (0) ; Methamphetamine (537-46-2) ; N-Methylaspartate (6384-92-5)

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