Drug interactions and the evolution of antibiotic resistance.

Full Abstract

Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.

Author information

Author/s: Yeh, Pamela J (PJ); Hegreness, Matthew J (MJ); Aiden, Aviva Presser (AP); Kishony, Roy (R);

Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Grants: R01GM081617 (Agency:NIGMS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Nature reviews. Microbiology (Nat Rev Microbiol), published in England. (Language: eng)

Reference: 2009-Jun; vol 7 (issue 6) : pp 460-6

Dates: Created 2009/05/15; Completed 2009/06/02;

PMID: 19444248, status: MEDLINE (last retrieved date: 6/2/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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