Effect of substrate and embedded metallic impurities of fullerene in the determination of nandrolone.

Full Abstract

A comparison of edge plane pyrolytic graphite substrate is made with other substrates like indium tin oxide, glassy carbon, gold and basal plane pyrolytic graphite as a substrate for fullerene modification for the determination of nandrolone by Osteryoung square wave voltammetry (OSWV) in phosphate buffer media. Comparative study of voltammetric response of nandrolone at untreated, purified and super-purified fullerene modified edge plane pyrolytic graphite electrode (EPPGE) is also carried out to determine the role of embedded metallic impurities of fullerene on determination of nandrolone. It is observed that EPPGE serves as best substrate among the studied for casting fullerene. The removal of embedded metals from fullerene shifts the peak potential of nandrolone to more positive potentials and peak current decreases. A linear calibration curve is obtained in the concentration range of 0.01-50 nM with a detection limit and sensitivity of 1.5 x 10(-11) M and 1.838 microA nM(-1), respectively. The developed method was satisfactorily applied to the determination of nandrolone in several commercially available medicinal samples.

Author information

Author/s: Goyal, Rajendra N (RN); Chatterjee, Sanghamitra (S); Bishnoi, Sunita (S);

Affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. rngcyfcy(-atsign-)iitr.ernet.in

Journal and publication information

Publication Type: Journal Article

Journal: Analytica chimica acta (Anal Chim Acta), published in Netherlands. (Language: eng)

Reference: 2009-Jun; vol 643 (issue 1-2) : pp 95-9

Dates: Created 2009/05/18; Completed 2009/07/17;

PMID: 19446069, status: MEDLINE (last retrieval date: 7/25/2009, IMS Date: )

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Associated Chemicals: Fullerenes (0) ; Phosphates (0) ; Tin Compounds (0) ; Nandrolone (434-22-0) ; indium tin oxide (71243-84-0) ; Carbon (7440-44-0) ; Gold (7440-57-5)

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