Research article summary (published 16 May 2009):

Central l-proline attenuates stress-induced dopamine and serotonin metabolism in the chick forebrain.

Full Abstract

Using microdialysis, we investigated the effect of l-proline on monoamine release in the medio-rostral neostriatum/hyperstriatum ventrale (MNH) of freely moving and restricted chicks. A 30 min handling-stress resulted in a significant increase in extracellular homovallinic acid (HVA), a dopamine metabolite, and 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite, in the MNH. l-Proline, perfused through the microdialysis probe into the MNH during the stressed condition, significantly attenuated the average dialysate concentration of HVA produced by handling-stress. Handling-stress resulted in a significant increase in 5-HIAA levels in the control group, which were attenuated by profusion with l-proline. l-Proline did not significantly modify basal concentrations of HVA or 5-HIAA in the MNH during control conditions. These results show that perfusion of l-proline modified the turnover/metabolism of dopamine and serotonin in the MNH caused by handling-stress.

Author information

Author/s: Hamasu, Kousuke (K); Shigemi, Kazutaka (K); Kabuki, Yusuke (Y); Tomonaga, Shozo (S); Denbow, D Michael (DM); Furuse, Mitsuhiro (M);

Affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)

Reference: 2009-Aug; vol 460 (issue 1) : pp 78-81

Dates: Created 2009/06/10; Completed 2009/09/01;

PMID: 19450655, status: MEDLINE (last retrieval date: 9/1/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance Animals Animals, Newborn Behavior, Animal Chickens Chromatography, High Pressure Liquid - methods Disease Models, Animal Dopamine - metabolism Drug Administration Routes

Electrochemistry - methods Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Male Microdialysis - methods Proline - administration & dosage Restraint, Physical - methods Serotonin - metabolism Stress, Psychological - drug therapy; etiology; metabolism

Associated Chemicals: Proline (147-85-3) ; Homovanillic Acid (306-08-1) ; Serotonin (50-67-9) ; Hydroxyindoleacetic Acid (54-16-0)

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