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| Research article summary (published 17 May 2009): |
A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI.
Full Abstract
OBJECTIVE: The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy ((1)H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker N-acetylaspartate (NAA) in patients with AD. Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS. METHODS: In total, 130 patients with dementia (98 AD, 32 non-AD), 136 subjects with MCI (70 of AD type, 66 of non-AD type), and 45 unimpaired control subjects were included. Single-volume (1)H-MRS of the left medial temporal lobe was performed at long and short echo times. Metabolites were quantified and metabolic ratios were determined. RESULTS: We found a significant reduction of NAA concentration in patients with AD as compared to healthy volunteers and compared to patients with MCI of AD type. NAA/Cr (creatine/phosphocreatine) was also lower in patients with AD compared to control subjects. NAA, choline compounds, and Cr were lower in patients with AD compared to patients with non-AD dementia. CONCLUSIONS: We demonstrated the multicenter feasibility of proton magnetic resonance spectroscopy ((1)H-MRS) of the medial temporal lobe in mild dementia and mild cognitive impairment, which is a prerequisite for the application of (1)H-MRS in large-scale clinical trials. Since the concentration measures of the metabolites are adjusted for brain tissue volume, these findings are indicators of biochemical pathology beyond brain atrophy.
Author information
Author/s: Jessen, F (F); Gür, O (O); Block, W (W); Ende, G (G); Frölich, L (L); Hammen, T (T); Wiltfang, J (J); Kucinski, T (T); Jahn, H (H); Heun, R (R); Maier, W (W); Kölsch, H (H); Kornhuber, J (J); Träber, F (F);
Affiliation: Department of Psychiatry, University of Bonn, Germany. Jessen(-atsign-)uni-bonn.de
Journal and publication information
Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal: Neurology (Neurology), published in United States. (Language: eng)
Reference: 2009-May; vol 72 (issue 20) : pp 1735-40
Dates: Created 2009/05/19; Completed 2009/06/01;
PMID: 19451528, status: MEDLINE (last retrieval date: 6/1/2009, IMS Date: 01 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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