Research article summary (published 30 Jul 2009):

5-HTTLPR modulates antidepressant efficacy in depressed women.

Full Abstract

BACKGROUND: As compared with the long variant (L), the short variant (S) of the functional polymorphic region of the serotonin transporter gene (5-HTTLPR) has been associated with a lower antidepressant efficacy in major depression, but some replication studies have evidenced contradictory results. Sex differences may explain these contradictory results. METHODS: One hundred and three inpatients (74 women and 29 men) with a major depressive episode were assessed prospectively for antidepressant efficacy after 4 weeks of treatment with selective serotonin reuptake inhibitors (SSRI) and non-SSRI drugs. RESULTS: As compared with LL/LS, the SS genotype of the 5-HTTLPR was associated with a lower antidepressant efficacy in depressed women (79 vs. 50% responders, P = 0.035). This result was shown with both SSRI and non-SSRI antidepressants. The logistic regression performed in women showed that response to treatment was related to genotype (odds ratio=0.15; 95% confidence interval=0.03-0.85; P = 0.03) and not to other variables. No effect of 5-HTTLPR was found in depressed men. CONCLUSION: Despite a low power, this study suggests a significant effect of 5-HTTLPR genotype on antidepressant efficacy in depressed women but not in men, with both SSRI and non-SSRI drugs. Further research is needed to confirm this result and investigate its underlying mechanisms.

Author information

Author/s: Gressier, Florence (F); Bouaziz, Elodie (E); Verstuyft, Céline (C); Hardy, Patrick (P); Becquemont, Laurent (L); Corruble, Emmanuelle (E);

Affiliation: Department of Psychiatry, Paris Sud University, Assistance Publique-Hôpitaux de Paris, Bicêtre University Hospital, France. fgressier(-atsign-)wanadoo.fr

Journal and publication information

Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't

Journal: Psychiatric genetics (Psychiatr Genet), published in England. (Language: eng)

Reference: 2009-Aug; vol 19 (issue 4) : pp 195-200

Dates: Created 2009/07/08; Completed 2009/11/03;

PMID: 19451862, status: MEDLINE (last retrieval date: 11/3/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Antidepressive Agents - therapeutic use Depressive Disorder - drug therapy; genetics Female Genotype Humans

Humans Male Pharmacogenetics Protein Isoforms - genetics; metabolism Serotonin Plasma Membrane Transport Proteins - genetics; metabolism Treatment Outcome

Associated Chemicals: Antidepressive Agents (0) ; Protein Isoforms (0) ; SLC6A4 protein, human (0) ; Serotonin Plasma Membrane Transport Proteins (0)

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