Research article summary (published 16 May 2009):

In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl.

Full Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Gan-kang granules (GKG) contains the extracts from eight Chinese herbs and is a traditional Chinese composite prescription for treatment of hepatitis B. Icariin, emodin and psoralen are main effective ingredients of the medicine. AIM OF THE STUDY: In this research, pharmacokinetic comparisons of icariin, emodin and psoralen from the extracts of herba Epimedii, Nepal dock root and Ficus hirta yahl, and GKG were conducted. MATERIALS AND METHODS: At different time points (0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h) after administration, the concentrations of icariin, emodin and psoralen in rat plasma were determined by HPLC-UV, and main pharmacokinetic parameters were estimated. RESULTS: The pharmacokinetic parameters of icariin, emodin and psoralen in GKG were elevated comparing with those of herb extracts. CONCLUSIONS: Three HPLC-UV methods were developed successfully for the analysis of icariin, emodin and psoralen in SD rat plasma. Some ingredients in GKG may increase the dissolution and absorption, and improve bioavailability of icariin, emodin and psoralen in rats.

Author information

Author/s: Li, Yihui (Y); Duan, Juping (J); Guo, Tingting (T); Xie, Wei (W); Yan, Shineng (S); Li, Bo (B); Zhou, Yanqin (Y); Chen, Yuxiang (Y);

Affiliation: School of Biological Sciences and Technology, Central South University, 172 Tongzipo Road, Changsha 410013, China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)

Reference: 2009-Jul; vol 124 (issue 3) : pp 522-9

Dates: Created 2009/07/27; Completed 2009/10/14;

PMID: 19454311, status: MEDLINE (last retrieval date: 10/14/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Calibration Chromatography, High Pressure Liquid Drug Stability Drug Synergism Drugs, Chinese Herbal - chemistry; pharmacology Emodin - pharmacokinetics Ficus - chemistry Ficusin - pharmacokinetics

Ficusin - pharmacokinetics Flavonoids - pharmacokinetics Plant Extracts - pharmacokinetics Quality Control Rats Reference Standards Reproducibility of Results Rumex - chemistry Spectrophotometry, Ultraviolet

Associated Chemicals: Drugs, Chinese Herbal (0) ; Flavonoids (0) ; Plant Extracts (0) ; epimedii flavone (0) ; gan-kang (0) ; icariin (489-32-7) ; Emodin (518-82-1) ; Ficusin (66-97-7)

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