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| Research article summary (published 30 May 2009): |
Influence of computer-aided detection false-positives on reader performance and diagnostic confidence for CT colonography.
Full Abstract
OBJECTIVE: The objective of our study was to investigate whether an increasing number of computer-aided detection (CAD) false-positives decreases reader sensitivity, specificity, and confidence for nonexpert readers of CT colonography (CTC). MATERIALS AND METHODS: Fifty CTC data sets (29 men; mean age, 65 years), 25 of which contained 35 polyps > or = 5 mm, were selected in which CAD had 100% polyp sensitivity at two sphericity settings (0 and 75) but differed in the number of false-positives. The data sets were read by five readers twice: once at each sphericity setting. Sensitivity, specificity, report time, and confidence before and after second-read CAD were compared using the paired exact and Student's t test, respectively. Receiver operating characteristic (ROC) curves were generated using reader confidence (1-100) in correct case classification (normal or abnormal). RESULTS: CAD generated a mean of 42 (range, 3-118) and 15 (range, 1-36) false-positives at a sphericity of 0 and 75, respectively. CAD at both settings increased per-patient sensitivity from 82% to 87% (p = 0.03) and per-polyp sensitivity by 8% and 10% for a sphericity of 0 and 75, respectively (p < 0.001). Specificity decreased from 84% to 79% (sphericity 0 and 75, p = 0.03 and 0.07). There was no difference in sensitivity, specificity, or reader confidence between sphericity settings (p = 1.0, 1.0, 0.11, respectively). The area under the ROC curve was 0.78 (95% CI, 0.70-0.86) and 0.77 (0.68-0.85) for a sphericity of 0 and 75, respectively. CAD added a median of 4.4 minutes (interquartile range [IQR], 2.7-6.5 minutes) and 2.2 minutes (IQR, 1.2-4.0 minutes) for a sphericity of 0 and 75, respectively (p < 0.001). CONCLUSION. CAD has the potential to increase the sensitivity of readers inexperienced with CTC, although specificity may be reduced. An increased number of CAD-generated false-positives does not negate any beneficial effect but does reduce efficiency.
Author information
Author/s: Taylor, Stuart A (SA); Brittenden, John (J); Lenton, James (J); Lambie, Hannah (H); Goldstone, Anthony (A); Wylie, Peter N (PN); Tolan, Damian (D); Burling, David (D); Honeyfield, Leslie (L); Bassett, Paul (P); Halligan, Steve (S);
Affiliation: Department of Specialist Imaging, University College Hospital, London, United Kingdom. csytaylor(-atsign-)yahoo.co.uk
Journal and publication information
Publication Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't
Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol), published in United States. (Language: eng)
Reference: 2009-Jun; vol 192 (issue 6) : pp 1682-9
Dates: Created 2009/05/21; Completed 2009/06/16;
PMID: 19457835, status: MEDLINE (last retrieval date: 6/16/2009, IMS Date: 16 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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