Research article summary (published 21 May 2009):

Effects of Ningdong granule on the dopamine system of Tourette's syndrome rat models.

Full Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Ningdong granula (NDG) is a traditional Chinese medicine (TCM) preparation for the treatment of Tourette's syndrome (TS). AIM OF THE STUDY: To explore the effects of NDG on stereotyped behavior, homovanillic acid (HVA) in sera, dopamine (DA) and dopamine D2 receptor (DRD2) in striatum in TS rats. MATERIALS AND METHODS: Sixty-four rats were randomly divided into control group and three experimental groups. TS rat models were induced by intraperitoneal injection (i.p.) of Apomorphine (Apo, 2 mg/kg) in the experimental groups. After Apo i.p., rats were intragastrically injected (i.g.) with NDG at 370 mg/kg (NDG+Apo group), haloperidol (Hal) at 1.0 mg/kg (Hal+Apo group), and normal saline (0.9%) at 10 ml/kg (control group and Apo group), respectively, once a day for 12 weeks. The behaviors of the rats were observed and recorded each day. After 12 weeks, all rats were sacrificed and sera and striatum were collected. The levels of HVA in sera, DA in striatum were examined by ELISA, and the expression of DRD2 mRNA in striatum was measured by RT-PCR. RESULTS: NDG could increase the HVA content in sera (P<0.05), meanwhile downregulate the expression of DRD2 mRNA in striatum (P<0.05), and inhibit the stereotyped behaviors induced by Apo (P<0.01) in TS rats, the same effects with Hal. NDG could also reduce the DA content in striatum (P<0.01), while Hal could not. CONCLUSIONS: NDG could effectively inhibit the stereotyped behaviors in TS rats, and the mechanisms may be related to the suppression of DA system by increasing the content of HVA in sera, decrease the content of DA and repressing the expression of DRD2 mRNA in striatum.

Author information

Author/s: Lv, Hong (H); Li, Anyuan (A); Ma, Hongbo (H); Liu, Fenye (F); Xu, Huanli (H);

Affiliation: Department of Traditional Chinese Medicine, Shandong Provincial Hospital affiliated to Shandong University, No. 324, Jingwuweqi Road, Jinan 250021, Shandong, PR China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of ethnopharmacology (J Ethnopharmacol), published in Ireland. (Language: eng)

Reference: 2009-Jul; vol 124 (issue 3) : pp 488-92

Dates: Created 2009/07/27; Completed 2009/10/14;

PMID: 19467315, status: MEDLINE (last retrieval date: 10/14/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Apomorphine - pharmacology Behavior, Animal - drug effects Chemistry, Pharmaceutical Dopamine - metabolism Dopamine Agents - pharmacology Dopamine Agonists - pharmacology Drugs, Chinese Herbal - pharmacology

Drugs, Chinese Herbal - pharmacology Homovanillic Acid - blood Medicine, Chinese Traditional Neostriatum - drug effects; metabolism Rats Rats, Wistar Receptors, Dopamine D2 - drug effects; metabolism Tourette Syndrome - metabolism

Associated Chemicals: Dopamine Agents (0) ; Dopamine Agonists (0) ; Drugs, Chinese Herbal (0) ; Receptors, Dopamine D2 (0) ; nindong (0) ; Homovanillic Acid (306-08-1) ; Apomorphine (58-00-4)

Related articles

These are the highest related articles currently in the database:

• Inhibitory effects of talipexole and pramipexole on MPTP-induced dopamine reduction in the striatum of C57BL/6N mice. 29 Apr 1997
• Amphetamine-induced enhancement of neostriatal in vivo microdialysate dopamine content in rats, quinpirole-primed as neonates. 29 Jun 2001
• Effects of bilateral ablation or 6-OHDA lesion of the frontal cortex upon the behaviors induced by apomorphine and amphetamine in adult cats. 30 Oct 1998
• Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat. 29 Nov 2001
• Altered mesolimbocortical and thalamic dopamine in Tourette syndrome. 12 Nov 2006
• High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats. 4 Sep 2007
• Effects of repeated administration of l-DOPA and apomorphine on circling behavior and striatal dopamine formation. 14 Feb 1998
• Antagonistic effects of OPC-14597, a novel antipsychotic drug, on quinpirole- and (-)-sulpiride-induced changes in evoked dopamine release in rat striatal slices. 30 Jan 1997
• Elevated striatal dopamine levels following administration of D-DOPA and its alpha-keto acid metabolite DHPPA: behavioral and physiological studies in vivo in the rat. 27 Apr 1996
• Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats. 16 Nov 2005

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.