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| Research article summary (published 30 May 2009): |
Stress, memory and the amygdala.
Full Abstract
Emotionally significant experiences tend to be well remembered, and the amygdala has a pivotal role in this process. But the efficient encoding of emotional memories can become maladaptive - severe stress often turns them into a source of chronic anxiety. Here, we review studies that have identified neural correlates of stress-induced modulation of amygdala structure and function - from cellular mechanisms to their behavioural consequences. The unique features of stress-induced plasticity in the amygdala, in association with changes in other brain regions, could have long-term consequences for cognitive performance and pathological anxiety exhibited in people with affective disorders.
Author information
Author/s: Roozendaal, Benno (B); McEwen, Bruce S (BS); Chattarji, Sumantra (S);
Affiliation: Department of Neuroscience, University Medical Center Groningen, University of Groningen, the Netherlands. b.roozendaal(-atsign-)med.umcg.nl
Grants: MH41256 (Agency:NIMH NIH HHS) ; MH58911 (Agency:NIMH NIH HHS) ; (Agency:Wellcome Trust)
Journal and publication information
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
Journal: Nature reviews. Neuroscience (Nat Rev Neurosci), published in England. (Language: eng)
Reference: 2009-Jun; vol 10 (issue 6) : pp 423-33
Dates: Created 2009/05/22; Completed 2009/06/09;
PMID: 19469026, status: MEDLINE (last retrieval date: 6/9/2009, IMS Date: 09 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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