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| Research article summary (published 24 May 2009): |
Reduced circulating angiogenic cells in Alzheimer disease.
Full Abstract
OBJECTIVE: Neurovascular dysfunction and senescent endothelium contribute to the progression of Alzheimer disease (AD). Circulating angiogenic cells (CACs), such as endothelial progenitor cells (EPCs), provide a cellular reservoir for the endothelial replacement. To study the involvement of CACs in AD pathogenesis, we investigated the levels of CACs in patients with AD. METHODS: Consecutive patients with newly diagnosed AD (n = 55), patients with non-AD neurodegenerative diseases (n = 37), and nondemented risk factor control subjects (RF control, n = 55 and 37) were enrolled after matching for age, sex, and Framingham risk score. Peripheral blood samples were taken, and EPC colony-forming units (CFU-EPC) were cultured and counted. RESULTS: The patients with AD had significantly lower CFU-EPC than the RF controls. In the patients with AD, a lower CFU-EPC was independently associated with either a lower Mini-Mental State Examination score or a higher Clinical Dementia Rating scale score, indicating a greater reduction in CFU-EPC in advanced AD. Patients with non-AD neurodegenerative diseases did not show a significant decrease in CFU-EPC levels. CONCLUSION: Our results indicate that patients with Alzheimer disease (AD) have reduced circulating angiogenic cells, suggesting that an abnormal capacity to regenerate endothelium is associated with AD.
Author information
Author/s: Lee, S-T (ST); Chu, K (K); Jung, K-H (KH); Park, H-K (HK); Kim, D-H (DH); Bahn, J-J (JJ); Kim, J-H (JH); Oh, M-J (MJ); Lee, S K (SK); Kim, M (M); Roh, J-K (JK);
Affiliation: Department of Neurology, Seoul National University Hospital, 101, Daehangno, Jongno-Gu, Seoul 110-744, South Korea.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neurology (Neurology), published in United States. (Language: eng)
Reference: 2009-May; vol 72 (issue 21) : pp 1858-63
Dates: Created 2009/05/27; Completed 2009/06/25; Revised 2009/08/18;
PMID: 19470969, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: 21 Aug 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
Comments and Corrections
ErratumIn: Neurology. 2009 Aug 18;73(7):573.
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