Research article summary (published 25 May 2009):

Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice.

Full Abstract

We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.

Author information

Author/s: Lee, Ki Yong (KY); Sung, Sang Hyun (SH); Kim, Seung Hyun (SH); Jang, Young Pyo (YP); Oh, Tae Hwan (TH); Kim, Young Choong (YC);

Affiliation: Seoul National University, Seoul, 151-742, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Archives of pharmacal research (Arch Pharm Res), published in Korea (South). (Language: eng)

Reference: 2009-May; vol 32 (issue 5) : pp 677-83

Dates: Created 2009/05/27; Completed 2009/06/29;

PMID: 19471881, status: MEDLINE (last retrieval date: 6/29/2009, IMS Date: 29 Jun 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetylcholinesterase - metabolism Administration, Oral Amnesia - chemically induced; drug therapy; enzymology; psychology Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Cholinesterase Inhibitors - administration & dosage; isolation & purification; pharmacology Cognition - drug effects Cornus - chemistry Disease Models, Animal Dose-Response Relationship, Drug

Dose-Response Relationship, Drug Fruit Hippocampus - drug effects; enzymology Iridoids - administration & dosage; isolation & purification; pharmacology Male Memory, Short-Term - drug effects Mice Mice, Inbred ICR Nootropic Agents - administration & dosage; isolation & purification; pharmacology Scopolamine Time Factors

Associated Chemicals: Cholinesterase Inhibitors (0) ; Iridoids (0) ; Nootropic Agents (0) ; loganin (18524-94-2) ; Scopolamine (51-34-3) ; Acetylcholinesterase (EC 3.1.1.7)

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