Research article summary (published 25 May 2009):

Subthreshold glutamate release from mitral cell dendrites.

Full Abstract

The dendrites of a number of neuron types function as presynaptic structures, releasing transmitter after action potentials and dendritic spikes. In this regard, dendrites can function like axons, producing discrete outputs after suprathreshold electrical events. However, as the major site of synaptic inputs, dendrites experience ongoing subthreshold fluctuations in membrane potential, raising the question of whether these subthreshold changes can cause changes in transmitter release. Here, we show that mitral cells of the accessory olfactory bulb release glutamate from their dendrites in response to both subthreshold and suprathreshold stimuli. Whereas subthreshold output was typically low under control conditions, it could be enhanced several fold by pharmacological or endogenous activation of group I metabotropic glutamate receptors. These results indicate that presynaptic dendrites can support two distinct forms of output, and can dynamically regulate how electrical activity is coupled to transmitter release.

Author information

Author/s: Castro, Jason B (JB); Urban, Nathaniel N (NN);

Affiliation: Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Grants: F31 DC08230 (Agency:NIDCD NIH HHS) ; R01 DC005798 (Agency:NIDCD NIH HHS)

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2009-May; vol 29 (issue 21) : pp 7023-30

Dates: Created 2009/05/28; Completed 2009/06/23; Revised 2009/07/14;

PMID: 19474329, status: MEDLINE (last retrieval date: 7/24/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Animals, Newborn Bicuculline - pharmacology Biophysics Calcium - metabolism Dendrites - drug effects; metabolism Dose-Response Relationship, Drug Drug Interactions Electric Stimulation - methods Excitatory Amino Acid Antagonists - pharmacology GABA Antagonists - pharmacology

GABA Antagonists - pharmacology Glutamic Acid - metabolism Inhibitory Postsynaptic Potentials - drug effects; physiology Membrane Potentials - drug effects; physiology Methoxyhydroxyphenylglycol - analogs & derivatives; pharmacology Mice Olfactory Bulb - cytology Patch-Clamp Techniques - methods Pyridazines - pharmacology Receptors, Metabotropic Glutamate - antagonists & inhibitors; physiology Sensory Receptor Cells - cytology

Associated Chemicals: Excitatory Amino Acid Antagonists (0) ; GABA Antagonists (0) ; Pyridazines (0) ; Receptors, Metabotropic Glutamate (0) ; gabazine (104104-50-9) ; dihydroxyphenylethylene glycol (3343-19-9) ; Bicuculline (485-49-4) ; Methoxyhydroxyphenylglycol (534-82-7) ; Glutamic Acid (56-86-0) ; Calcium (7440-70-2)

Related articles

These are the highest related articles currently in the database:

• Group I metabotropic glutamate receptors are differentially expressed by two populations of olfactory bulb granule cells. 8 Jan 2007
• Opposing inward and outward conductances regulate rebound discharges in olfactory mitral cells. 4 Dec 2006
• SK channel regulation of dendritic excitability and dendrodendritic inhibition in the olfactory bulb. 15 Aug 2005
• Tufted cell dendrodendritic inhibition in the olfactory bulb is dependent on NMDA receptor activity. 30 Dec 2000
• Dendritic sodium spikelets and low-threshold calcium spikes in turtle olfactory bulb granule cells. 11 Oct 2004
• Direct inhibitory effect of taurine on relay neurones of the rat olfactory bulb in vitro. 11 Jul 1998
• Bicuculline induces synapse formation on primary cultured accessory olfactory bulb neurons. 30 Aug 2003
• Functional role of NMDA autoreceptors in olfactory mitral cells. 29 Jun 2000
• Long-term depression at olfactory nerve synapses. 25 Apr 2005
• Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. 17 May 2000

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.