Research article summary (published 30 Aug 2009):

Neuroprotective effects of estrogen therapy for cognitive and neurobiological profiles of monkey models of menopause.

Full Abstract

Many postmenopausal women question whether to start or continue hormone therapy because of recent clinical trial negative results. However, evidence from other studies of postmenopausal women, and from studies in menopausal monkeys, indicate that estrogen has neurocognitive protective effects, particularly when therapy is initiated close to the time of menopause before neural systems become increasingly compromised with age. In this review, we present studies of menopausal women and female monkeys that support the concept that estrogen therapies protect both cognitive function and neurobiological processes.

Author information

Author/s: Voytko, Mary Lou (ML); Tinkler, Gregory Paul (GP); Browne, Carole (C); Tobin, Joseph R (JR);

Affiliation: Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mlvoytko(-atsign-)wfubmc.edu

Grants: AG13204 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Review

Journal: American journal of primatology (Am J Primatol), published in United States. (Language: eng)

Reference: 2009-Sep; vol 71 (issue 9) : pp 794-801

Dates: Created 2009/08/03; Completed 2009/11/02;

PMID: 19475542, status: MEDLINE (last retrieved date: 11/2/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Age Factors Animals Brain - drug effects; pathology Cognition - drug effects Estrogen Replacement Therapy - statistics & numerical data Estrogens - pharmacology Female

Female Humans Menopause - metabolism Models, Animal Neuroprotective Agents - pharmacology Receptors, Neurotransmitter - metabolism Synapses - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Estrogens (0) ; Neuroprotective Agents (0) ; Receptors, Neurotransmitter (0)

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