Research article summary (published 30 May 2009):

Three new 7.3',8.5'-connected bicyclo[3.2.1]octanoids and other neolignans from leaves of Nectandra amazonum NEES. (Lauraceae).

Full Abstract

Three new 7.3',8.5'-connected (macrophyllin-type) bicyclo[3.2.1]octanoid neolignans (nectamazins A-C, 1-3) were isolated from leaves of Nectandra amazonum NEES., along with seven known neolignans (4-10). The structures of 1-3 were characterized by spectroscopic methods (1D, 2D NMR) and the absolute configuration was assigned on the basis of circular dichroism (CD) spectra supported by nuclear Overhauser effect spectroscopy (NOESY) correlations. The new compounds showed inhibition activity against platelet activating factor (PAF)-induced aggregation of rabbit platelets.

Author information

Author/s: Coy Barrera, Ericsson David (ED); Cuca Suárez, Luis Enrique (LE);

Affiliation: Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Investigación en Productos Naturales Vegetales, AA 14490, Cra 30 45-03, Ciudad Universitaria, Bogotá D.C., Colombia.

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't

Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)), published in Japan. (Language: eng)

Reference: 2009-Jun; vol 57 (issue 6) : pp 639-42

Dates: Created 2009/06/01; Completed 2009/07/02;

PMID: 19483352, status: MEDLINE (last retrieval date: 7/2/2009, IMS Date: 02 Jul 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Carbohydrate Conformation Circular Dichroism Ethanol Ginkgo biloba - chemistry Lauraceae - chemistry Lignans - chemistry; isolation & purification; pharmacology Magnetic Resonance Spectroscopy

Models, Molecular Plant Extracts - chemistry Plant Leaves - chemistry Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry; isolation & purification; pharmacology Rabbits Solvents Spectrometry, Mass, Electrospray Ionization

Associated Chemicals: Lignans (0) ; Plant Extracts (0) ; Platelet Aggregation Inhibitors (0) ; Solvents (0) ; nectamazin A (0) ; nectamazin B (0) ; nectamazin C (0) ; Ethanol (64-17-5)

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