Research article summary (published 13 Aug 2009):

Semiparametric ROC surfaces for continuous diagnostic tests based on two test measurements.

Full Abstract

We propose a semiparametric method for estimating ROC surfaces for continuous diagnostic tests based on two test measurements. Such a three-class diagnostic problem based on two test measurements arises naturally from some DNA amplification-related diagnostic scenarios. Simulation results show that our proposed semiparametric ROC surface estimator is more efficient than the nonparametric counterpart and is quite comparable with the parametric counterpart when model assumption of the data is correctly specified for the parametric method. Moreover, when the parametric model assumption is not true, our proposed semiparametric method is superior to both nonparametric and parametric methods. Some discussions and a simulated example along with R programs for implementation of the proposed method are also provided. Copyright 2009 John Wiley & Sons, Ltd.

Author information

Author/s: Wan, Shuwen (S); Zhang, Biao (B);

Affiliation: Department of Applied Mathematics, Nanjing University of Finance & Economics, Nanjing 210046, China. wanshuwen(-atsign-)yahoo.com.cn

Journal and publication information

Publication Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't

Journal: Statistics in medicine (Stat Med), published in England. (Language: eng)

Reference: 2009-Aug; vol 28 (issue 18) : pp 2370-83

Dates: Created 2009/07/14; Completed 2009/10/01;

PMID: 19499550, status: MEDLINE (last retrieval date: 10/1/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biometry Diagnostic Tests, Routine - statistics & numerical data Humans Likelihood Functions Logistic Models Models, Statistical

Models, Statistical Mycobacterium tuberculosis - genetics; isolation & purification Nucleic Acid Amplification Techniques - statistics & numerical data ROC Curve Statistics, Nonparametric Tuberculosis, Pulmonary - diagnosis

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