Developmental vitamin D deficiency alters dopamine turnover in neonatal rat forebrain.

Full Abstract

There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development.

Author information

Author/s: Kesby, James P (JP); Cui, Xiaoying (X); Ko, Pauline (P); McGrath, John J (JJ); Burne, Thomas H J (TH); Eyles, Darryl W (DW);

Affiliation: School of Biomedical Science, University of Queensland, Qld 4072, Australia.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuroscience letters (Neurosci Lett), published in Ireland. (Language: eng)

Reference: 2009-Sep; vol 461 (issue 2) : pp 155-8

Dates: Created 2009/07/13; Completed 2009/09/23;

PMID: 19500655, status: MEDLINE (last retrieval date: 9/23/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Monoamine Oxidase - biosynthesis
Norepinephrine - metabolism
Pregnancy
Pregnancy Complications - metabolism
Prosencephalon - growth & development; metabolism
Rats
Rats, Sprague-Dawley
Serotonin - metabolism
Signal Transduction
Vitamin D Deficiency - embryology; metabolism

Associated Chemicals: 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Homovanillic Acid (306-08-1) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Hydroxyindoleacetic Acid (54-16-0) ; Monoamine Oxidase (EC 1.4.3.4) ; Catechol O-Methyltransferase (EC 2.1.1.6)

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