Research article summary (published 27 Feb 2009):

[The pathobiochemistry of Dupuytren's contracture]

(Patobiochemia przykurczu Dupuytrena.)

Full Abstract

Dupuytren's contracture is a connective tissue disorder characterized by nodular fibroblastic proliferation of palmar fascia leading to a shortening and progressive digital flexion deformity. It seems that this pathological process is initiated by the differentiation of fibroblast into myofibroblast which has morphologic characteristic of both fibroblast and a smooth muscle cell. Myofibroblasts are able to biosynthesize and secrete growth factors which subsequently bind to the receptors anchored on its surface, bringing about an autocrine and paracrine modality of control cell growth, differentiation and proliferation. It leads to imbalance in the metabolism of extracellular matrix molecules, especially collagen, elastin, fibronectin, laminin, proteoglycan and others, finally damaging mechanical properties of palmar aponeurosis. This rewiev highlights mechanism and many of mentioned factors potentially involved in the development of Dupuytren's disease.

Author information

Author/s: Bobinski, Rafal (R);

Affiliation: Wydzial Nauk o Zdrowiu, Akademia Techniczno-Humanistyczna w Bielsku-Bialej. rbobinski(-atsign-)ath.bielsko.pl

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Chirurgia narzadów ruchu i ortopedia polska (Chir Narzadow Ruchu Ortop Pol), published in Poland. (Language: pol)

Reference: -2009 Mar-Apr; vol 74 (issue 2) : pp 68-73

Dates: Created 2009/06/11; Completed 2009/08/11;

PMID: 19514484, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Dupuytren's Contracture - metabolism; pathology Extracellular Matrix - metabolism Fibroblasts - metabolism Humans

Humans Muscle, Smooth - metabolism Platelet-Derived Growth Factor - metabolism Transforming Growth Factor beta - metabolism

Associated Chemicals: Platelet-Derived Growth Factor (0) ; Transforming Growth Factor beta (0)

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