Trisulfonated porphyrazines: new photosensitizers for the treatment of retinal and subretinal edema.

Full Abstract

A new series of water-soluble, mononaphthotrisulfobenzoporphyrazines, bearing an alkynyl side chain of varying lengths on the naphtho ring, were prepared and tested for their efficacy to inhibit plasma extravasation when used as photosensitizers during photodynamic therapy (PDT) of the retina in the rat. The hexynyl substituted photosensitizer was the most potent, and was able to produce complete inhibition, at low doses of photosensitizer and light.

Author information

Author/s: van Lier, Johan E (JE); Tian, Hongjian (H); Ali, Hasrat (H); Cauchon, Nicole (N); Hasséssian, Haroutioun M (HM);

Affiliation: Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada. johan.e.vanlier(-atsign-)usherbrooke.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of medicinal chemistry (J Med Chem), published in United States. (Language: eng)

Reference: 2009-Jul; vol 52 (issue 14) : pp 4107-10

Dates: Created 2009/07/16; Completed 2009/08/25;

PMID: 19514748, status: MEDLINE (last retrieval date: 8/25/2009, IMS Date: )

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