Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling.

Full Abstract

Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber growth and maintenance. In zebrafish embryos, gain-of-Wnt/beta-catenin function results in unscheduled muscle progenitor proliferation, leading to slow and fast muscle hypertrophy accompanied by fast muscle degeneration. The effects of Wnt/beta-catenin signaling on fast muscle hypertrophy were rescued by misexpression of Myostatin or p21(CIP/WAF), establishing an in vivo regulation of myofibrillogenesis by Wnt/beta-catenin signaling and Myostatin. Epistatic analyses suggest a possible genetic interaction between Wnt/beta-catenin and Myostatin in regulation of slow and fast twitch muscle myofibrillogenesis.

Author information

Author/s: Tee, Jin-Ming (JM); van Rooijen, Carina (C); Boonen, Rick (R); Zivkovic, Danica (D);

Affiliation: Hubrecht Institute for Developmental Biology and Stem Cell Research and University Medical Center, Utrecht, The Netherlands.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: PloS one (PLoS One), published in United States. (Language: eng)

Reference: 2009-; vol 4 (issue 6) : pp e5880

Dates: Created 2009/06/11; Completed 2009/11/17;

PMID: 19517013, status: MEDLINE (last retrieved date: 11/17/2009)

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