A novel gel based vehicle for the delivery of acetylcholine in quantitative sudomotor axon reflex testing.

Full Abstract

This study describes a novel gel based vehicle for the delivery of acetylcholine (ACh) during quantitative sudomotor axon reflex testing (QSART). A dose and current response study were undertaken on 20 healthy control participants to characterize the efficiency of a gel based vehicle for the delivery of ACh. Values obtained for total sweat volume and latency to sweat onset with gel iontophoresis of ACh during QSART were comparable to previously published normative data using solution based vehicles. Patient discomfort, utilizing the gel based vehicle during the QSART procedure, was minimal. Improvement in iontophoresis using the gel formulation as a vehicle for ACh delivery has the potential to lower the voltage required to overcome skin resistance during QSART and may result in improved patient comfort during the procedure.

Author information

Author/s: Sletten, David M (DM); Kimpinski, Kurt (K); Weigand, Stephen D (SD); Low, Phillip A (PA);

Affiliation: Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Grants: NS 32352 (Agency:NINDS NIH HHS) ; NS 43364 (Agency:NINDS NIH HHS) ; NS 44233 (Agency:NINDS NIH HHS) ; UL1 RR24150 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Autonomic neuroscience : basic & clinical (Auton Neurosci), published in Netherlands. (Language: eng)

Reference: 2009-Oct; vol 150 (issue 1-2) : pp 127-30

Dates: Created 2009/09/07; Completed 2009/11/16;

PMID: 19520617, status: MEDLINE (last retrieved date: 11/16/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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