Research article summary (published 29 Sep 2009):

A recombinant-based ELISA evaluating the efficacy of netobimin and albendazole in ruminants with naturally acquired fascioliasis.

Full Abstract

The therapeutic efficacy of albendazole and netobimin in ruminants with naturally occurring fascioliasis was investigated using a recombinant-based ELISA. The variation in the IgG response against a 2.9-kDa recombinant protein (FhrAPS), termed efficacy index (EI) 1, and the egg-output changes, termed EI 2, were used to evaluate drug efficacy. The values of EI 1 ranged between 0% and 50% in sheep, and between 0% and 30% in cattle after treatment with albendazole and netobimin. Similar EI 2 values were observed in sheep receiving albendazole or netobimin, but the highest values were found in cattle treated with netobimin. The significant reduction in the IgG response to FhrAPS found in this study shows promise in terms of developing alternative methods for evaluating the efficacy of chemotherapy against Fasciola hepatica in grazing ruminants.

Author information

Author/s: Arias, María Sol (MS); Suárez, José Luis (JL); Hillyer, G V (GV); Francisco, Iván (I); Calvo, Enrique (E); Sánchez-Andrade, Rita (R); Díaz, Pablo (P); Francisco, Rubén (R); Díez-Baños, Pablo (P); Morrondo, Patrocinio (P); Paz-Silva, Adolfo (A);

Affiliation: Animal Pathology Department, Epidemiology, Zoonoses and Parasitic Diseases, Veterinary Faculty, Santiago de Compostela University, 27002 Lugo, Spain.

Grants: G12 RR03051 (Agency:NCRR NIH HHS) ; S06 GM08224 (Agency:NIGMS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Veterinary journal (London, England : 1997) (Vet J), published in England. (Language: eng)

Reference: 2009-Oct; vol 182 (issue 1) : pp 73-8

Dates: Created 2009/06/15; Completed 2009/07/22; Revised 2009/08/20;

PMID: 19524206, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Albendazole - therapeutic use Animals Anthelmintics - therapeutic use Antibodies, Helminth - blood; immunology Cattle Cattle Diseases - drug therapy Enzyme-Linked Immunosorbent Assay - standards; veterinary Fasciola hepatica - immunology Fascioliasis - drug therapy; veterinary Feces - parasitology Female

Female Guanidines - therapeutic use Helminth Proteins - immunology Immunoglobulin G - blood; immunology Parasite Egg Count - veterinary Random Allocation Recombinant Proteins - immunology Sensitivity and Specificity Sheep Sheep Diseases - drug therapy Treatment Outcome

Associated Chemicals: Anthelmintics (0) ; Antibodies, Helminth (0) ; Guanidines (0) ; Helminth Proteins (0) ; Immunoglobulin G (0) ; Recombinant Proteins (0) ; Albendazole (54965-21-8) ; netobimin (88255-01-0)

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