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| Research article summary (published 9 Jun 2009): |
Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events.
Full Abstract
The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.
Author information
Author/s: Joshua, Mati (M); Adler, Avital (A); Prut, Yifat (Y); Vaadia, Eilon (E); Wickens, Jeffery R (JR); Bergman, Hagai (H);
Affiliation: Department of Physiology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel. mati(-atsign-)alice.nc.huji.ac.il
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Neuron (Neuron), published in United States. (Language: eng)
Reference: 2009-Jun; vol 62 (issue 5) : pp 695-704
Dates: Created 2009/06/15; Completed 2009/06/26;
PMID: 19524528, status: MEDLINE (last retrieval date: 6/26/2009, IMS Date: 26 Jun 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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