Research article summary (published 11 Jun 2009):

Pubertal isolation alters latent inhibition and DA in nucleus accumbens of adult rats.

Full Abstract

Puberty is a critical period for neurodevelopment of schizophrenia. In the present study, we investigated the effects of peri-pubertal social isolation on psychotic behaviors in rats and its relationship to dopamine expression. Wistar male rats were randomly divided into pubertal isolation (ISO; isolate housing, 38-51 days of age) and social (SOC) groups. Latent inhibition (LI) and behavior in open field were tested during adolescence and adulthood. After the behavioral test, dopamine (DA) levels were measured in the medial prefrontal cortex (mPFC), nucleus accumbens (NAC), caudate-putamen (CPU), and the hippocampus (HIP). Pubertal social isolation impaired LI and increased the DA level in the NAC of young adult rats, but not adolescent rats, and enhanced open field locomotor activity in both adolescent and young adult rats. These data suggest that development of an LI deficit can be induced by social isolation during puberty after a developmental delay, and that NAC DA maybe involved in this process, which may mirror some aspects of the ontogency of schizophrenic symptoms.

Author information

Author/s: Shao, Feng (F); Jin, Jian (J); Meng, Qingxuan (Q); Liu, Mei (M); Xie, Xi (X); Lin, Wenjuan (W); Wang, Weiwen (W);

Affiliation: Department of Psychology, Peking University, Beijing 100871, China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Physiology & behavior (Physiol Behav), published in United States. (Language: eng)

Reference: 2009-Sep; vol 98 (issue 3) : pp 251-7

Dates: Created 2009/08/11; Completed 2009/10/27;

PMID: 19527740, status: MEDLINE (last retrieval date: 10/27/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aging - physiology Animals Conditioning, Classical - physiology Dopamine - metabolism Hippocampus - metabolism Male Motor Activity - physiology Neostriatum - metabolism

Neostriatum - metabolism Nucleus Accumbens - metabolism Prefrontal Cortex - metabolism Random Allocation Rats Rats, Wistar Sexual Maturation - physiology Social Isolation - psychology

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