Research article summary (published 30 Jul 2009):

Effect of Korean red ginseng on superoxide dismutase inhibitor-induced pancreatitis in rats: a histopathologic and immunohistochemical study.

Full Abstract

OBJECTIVES: Korean red ginseng (KRG) is a representative herbal remedy in Korea. We examined the effects of KRG treatment on superoxide dismutase inhibitor-induced experimental pancreatitis. METHODS: Sprague-Dawley rats and KRG from the roots of a 6-year-old fresh Panax ginseng C. A. Meyer plant were used in this study. Pancreatitis was induced by intraperitoneal injection of diethyldithiocarbamate for 4 weeks. Korean red ginseng was fed orally to rats for the next 3 weeks. At week 7, all rats were killed, and pancreatic tissues were analyzed. RESULTS: No histological alterations were detected in the pancreata of normal and KRG control groups. Tissues from the non-KRG-treated pancreatitis group exhibited marked pancreatic damage including changes in histological architecture, acinar cell necrosis and degeneration, and cytoplasmic vacuolization. However, tissues from the KRG-treated pancreatitis group exhibited no cellular damage and had normal histological pancreatic architecture. Immunohistochemical examination revealed that the expressions of nuclear factor kappaB, tumor necrosis factor alpha, inducible nitric oxide synthase, and the oxidant stress markers, malondialdehyde and 4-hydroxynonenal, were significantly decreased in the KRG-treated pancreatitis group as compared with the non-KRG-treated pancreatitis group. CONCLUSIONS: Our results suggest that KRG has antioxidant therapeutic effects on superoxide dismutase inhibitor-induced pancreatitis by inhibition of nuclear factor kappaB.

Author information

Author/s: Joo, Kwang Ro (KR); Shin, Hyun Phil (HP); Cha, Jae Myung (JM); Nam, Sua (S); Huh, Youngbuhm (Y);

Affiliation: Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea. krjoo(-atsign-)khu.ac.kr

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Pancreas (Pancreas), published in United States. (Language: eng)

Reference: 2009-Aug; vol 38 (issue 6) : pp 661-6

Dates: Created 2009/07/29; Completed 2009/11/04;

PMID: 19531970, status: MEDLINE (last retrieved date: 11/4/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Antioxidants - pharmacology Ditiocarb - toxicity Drugs, Chinese Herbal - pharmacology Enzyme Inhibitors - toxicity Korea Male NF-kappa B - metabolism Nitric Oxide Synthase Type II - metabolism

Oxidative Stress - drug effects Panax Pancreatitis - chemically induced; drug therapy; metabolism; pathology Peroxidase - metabolism Phytotherapy Rats Rats, Sprague-Dawley Superoxide Dismutase - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antioxidants (0) ; Drugs, Chinese Herbal (0) ; Enzyme Inhibitors (0) ; NF-kappa B (0) ; Tumor Necrosis Factor-alpha (0) ; Ditiocarb (147-84-2) ; Peroxidase (EC 1.11.1.7) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39) ; Superoxide Dismutase (EC 1.15.1.1)

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