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| Research article summary (published 30 Aug 2009): |
Subjects with intellectual disability and familial need for full-time special education show regional brain alterations: a voxel-based morphometry study.
Full Abstract
Subjects attending full-time special education (SE) often have multifactorial background for their cognitive impairment, and brain MRI may show nonspecific changes. As voxel-based morphometry reveals regional volume differences, we applied this method to 119 subjects with cognitive impairments and familial need for full-time SE--graded into three levels from specific disorders of cognitive processes (level 1) to intellectual disability (IQ <70; level 3)--and to 43 age-matched controls attending mainstream education (level 0). Subjects in SE groups had smaller global brain white matter (WM), cerebrospinal fluid, and total brain volume than controls. Compared with controls, subjects with intellectual disabilities in SE level 3 showed greater regional gray matter volumes bilaterally in the ventral and dorsal anterior cingulate cortex and smaller regional gray matter volumes in the left thalamus and cerebellar hemisphere. Further, they had greater WM volume in the left frontoparietal region and smaller WM volumes in the posterior limbs of the internal capsules. Subjects in SE level 1 and 2 groups showed the same tendency, but the results were nonsignificant. In conclusion, compared with controls, subjects with intellectual disabilities showed in voxel-based morphometry analysis several regional brain alterations.
Author information
Author/s: Mannerkoski, Minna K (MK); Heiskala, Hannu J (HJ); Van Leemput, Koen (K); Aberg, Laura E (LE); Raininko, Raili (R); Hämäläinen, Janne (J); Autti, Taina H (TH);
Affiliation: Department of Gynecology and Pediatrics, Helsinki University Central Hospital, 00290 Helsinki, Finland. minna.mannerkoski(-atsign-)hus.fi
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Pediatric research (Pediatr Res), published in United States. (Language: eng)
Reference: 2009-Sep; vol 66 (issue 3) : pp 306-11
Dates: Created 2009/08/20; Completed 2009/10/27;
PMID: 19531975, status: MEDLINE (last retrieval date: 10/27/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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