Research article summary (published 18 Jun 2009):

Effect of emodin on Candida albicans growth investigated by microcalorimetry combined with chemometric analysis.

Full Abstract

Using the 3114/3115 thermal activity monitor (TAM) air isothermal microcalorimeter, ampoule mode, the heat output of Candida albicans growth at 37 degrees C was measured, and the effect of emodin on C. albicans growth was evaluated by microcalorimetry coupled with chemometric methods. The similarities between the heat flow power (HFP)-time curves of C. albicans growth affected by different concentrations of emodin were calculated by similarity analysis (SA). In the correspondence analysis (CA) diagram of eight quantitative parameters taken from the HFP-time curves, it could be deduced that emodin had definite dose-effect relationship as the distance between different concentrations of it increased along with the dosage and the effect. From the principal component analysis (PCA) on eight quantitative parameters, the action of emodin on C. albicans growth could be easily evaluated by analyzing the change of values of the main two parameters, growth rate constant k (2) and maximum power output P(2)(m). The coherent results of SA, CA, and PCA showed that emodin at different concentrations had different effects on C. albicans growth metabolism: A low concentration (0-10 microg ml(-1)) poorly inhibited the growth of C. albicans, and a high concentration (15-35 microg ml(-1)) could notably inhibit growth of this fungus. This work provided a useful idea of the combination of microcalorimetry and chemometric analysis for investigating the effect of drug and other compounds on microbes.

Author information

Author/s: Kong, W J (WJ); Wang, J B (JB); Jin, C (C); Zhao, Y L (YL); Dai, C M (CM); Xiao, X H (XH); Li, Z L (ZL);

Affiliation: China Military Institute of Chinese Materia Medica, Military Hospital of China, Beijing, People's Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Applied microbiology and biotechnology (Appl Microbiol Biotechnol), published in Germany. (Language: eng)

Reference: 2009-Jul; vol 83 (issue 6) : pp 1183-90

Dates: Created 2009/07/06; Completed 2009/08/26;

PMID: 19543891, status: MEDLINE (last retrieval date: 8/26/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Antifungal Agents - pharmacology Calorimetry - methods Candida albicans - drug effects; growth & development Dose-Response Relationship, Drug

Dose-Response Relationship, Drug Emodin - pharmacology Growth Inhibitors - pharmacology Molecular Structure

Associated Chemicals: Antifungal Agents (0) ; Growth Inhibitors (0) ; Emodin (518-82-1)

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