Research article summary (published 22 Jun 2009):

DHPG activation of group 1 mGluRs in BLA enhances fear conditioning.

Full Abstract

Group 1 metabotropic glutamate receptors are known to play an important role in both synaptic plasticity and memory. We show that activating these receptors prior to fear conditioning by infusing the group 1 mGluR agonist, (R.S.)-3,5-dihydroxyphenylglycine (DHPG), into the basolateral region of the amygdala (BLA) of adult Sprague-Dawley rats enhances freezing normally supported by a weak footshock. This effect of DHPG was blocked when it was co-infused with either the general group 1 mGluR1 antagonist, (R,S)-1-aminoindan-1,5 dicarboxylic acid (AIDA), or with the selective mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP). These results support previous findings by Rodrigues and colleagues that mGluR5s in the lateral region of the amygdala make an import contribution to fear conditioning. More importantly, they support the general ideas embedded in the concept of metaplasticity, as per Abraham, and the synaptic-tagging hypothesis per Frey and Morris-that the processes that specify the content of experience can be experimentally separated from those needed to acquire the memory.

Author information

Author/s: Rudy, Jerry W (JW); Matus-Amat, Patricia (P);

Affiliation: Department of Psychology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA. JRudy(-atsign-)Clipr.Colorado.

Grants: R01 MH61316 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Learning & memory (Cold Spring Harbor, N.Y.) (Learn Mem), published in United States. (Language: eng)

Reference: 2009-; vol 16 (issue 7) : pp 421-5

Dates: Created 2009/06/25; Completed 2009/09/07;

PMID: 19553379, status: MEDLINE (last retrieval date: 9/7/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acoustic Stimulation - methods Amygdala - drug effects; metabolism Animals Conditioning, Classical - drug effects; physiology Drug Administration Schedule Electroshock - adverse effects Excitatory Amino Acid Antagonists - pharmacology Fear Freezing Reaction, Cataleptic - drug effects

Freezing Reaction, Cataleptic - drug effects Indans - pharmacology Male Methoxyhydroxyphenylglycol - analogs & derivatives; pharmacology Microinjections - methods Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate - agonists; physiology Time Factors

Associated Chemicals: 1-aminoindan-1,5-dicarboxylic acid (0) ; Excitatory Amino Acid Antagonists (0) ; Indans (0) ; Receptors, Metabotropic Glutamate (0) ; metabotropic glutamate receptor type 1 (0) ; dihydroxyphenylethylene glycol (3343-19-9) ; Methoxyhydroxyphenylglycol (534-82-7)

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