Research article summary (published 29 Sep 2009):

N-type calcium channels mediate a GABA(B) presynaptic modulation in the corticostriatal synapse in turtle's paleostriatum augmentatum.

Full Abstract

Spikes population evoked by a paired pulse protocol were used to assess the influence of GABA(A) and GABA(B) receptors agonists and antagonists on the synaptic potentials and in the S2/S1 ratio in a paired pulse (PP) protocol in the cortico-paleostriatum augmentatum synapses of the turtle. GABA(A) agonist, muscimol, decreased the amplitude of synaptic responses whereas the facilitation produced with the PP protocol did not change, suggesting a postsynaptic action for GABA(A) receptors. GABA(B) agonist, baclofen, enhanced paired pulse ratio indicating a presynaptic modulation through the GABA(B) receptor. Selective antagonists for N- and P/Q-type Ca(2+)-channels also enhanced paired pulse ratio, suggesting that any of these channel types may be involved in neurotransmitter release. However, the strong paired pulse facilitation produced by baclofen was occluded by blocking the N-type Ca2+ channels with omega-conotoxin GVIA (1 microM), but not by the blockage of P/Q-type Ca2+ channels with omega-agatoxin TK (400 nM). These data suggest that N and P/Q channels participate in the neurotransmitter release, whereas only N-type Ca2+ channels are involved in the presynaptic modulation of GABA(B) in the corticostriatal synapse of the turtle. Copyright 2009 Wiley-Liss, Inc.

Author information

Author/s: Sánchez-Mejorada, Eduardo (E); Sánchez-Mondragon, Guadalupe (G); Pineda, Juan Carlos (JC); González, Mónica (M); Barral, Jaime (J);

Affiliation: Neurociencias (UIICSE), FES Iztacala, UNAM, México.

Journal and publication information

Publication Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't

Journal: Synapse (New York, N.Y.) (Synapse), published in United States. (Language: eng)

Reference: 2009-Oct; vol 63 (issue 10) : pp 855-62

Dates: Created 2009/08/11; Completed 2009/10/26;

PMID: 19562696, status: MEDLINE (last retrieval date: 10/26/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Action Potentials - drug effects; physiology Animals Biophysics Calcium Channel Blockers - pharmacology Calcium Channels, N-Type - physiology Cerebral Cortex - physiology Corpus Striatum - cytology Dose-Response Relationship, Drug

Drug Interactions Electric Stimulation - methods Excitatory Amino Acid Antagonists - pharmacology GABA Agents - pharmacology Presynaptic Terminals - drug effects; physiology Receptors, GABA-B - agonists; antagonists & inhibitors; metabolism Synapses - drug effects; physiology Turtles Valine - analogs & derivatives; pharmacology

Associated Chemicals: Calcium Channel Blockers (0) ; Calcium Channels, N-Type (0) ; Excitatory Amino Acid Antagonists (0) ; GABA Agents (0) ; Receptors, GABA-B (0) ; 6-Cyano-7-nitroquinoxaline-2,3-dione (115066-14-3) ; Valine (7004-03-7) ; 2-amino-5-phosphopentanoic acid (76326-31-3)

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