Research article summary (published 30 Jul 2009):

The variable clinical picture of drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms in relation to the eliciting drug.

Full Abstract

Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a life-threatening adverse reaction characterized by skin rashes, fever, leukocytosis with eosinophilia or atypical lymphocytosis, lymph node enlargement, and liver or renal dysfunction. The syndrome develops 2 to 6 weeks after initiation of administration of a specific drug. It has been demonstrated that various herpesvirus reactivations, in addition to human herpesvirus 6, contribute to internal organ involvement and the relapse of symptoms observed long after discontinuation of the causative drugs. A better understanding of the interplay in the development of DIHS/DRESS has implications for safer and more efficient treatment of this syndrome.

Author information

Author/s: Kano, Yoko (Y); Shiohara, Tetsuo (T);

Affiliation: Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan. kano(-atsign-)ks.kyorin-u.ac.jp

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am), published in United States. (Language: eng)

Reference: 2009-Aug; vol 29 (issue 3) : pp 481-501

Dates: Created 2009/06/30; Completed 2009/10/22;

PMID: 19563993, status: MEDLINE (last retrieval date: 10/22/2009, IMS Date: 22 Oct 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Diagnosis, Differential Drug Eruptions Drug Hypersensitivity - complications; diagnosis; immunology; physiopathology Eosinophilia Exanthema Herpesvirus 6, Human - immunology Humans

Humans Lupus Erythematosus, Systemic - complications; diagnosis; immunology; pathology; physiopathology Renal Insufficiency Roseolovirus Infections - complications; immunology Sepsis Time Factors Withholding Treatment

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