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| Research article summary (published 30 Jul 2009): |
In vitro tests in drug hypersensitivity diagnosis.
Full Abstract
The diagnosis of a drug hypersensitivity reaction (DHR) is a challenging task because multiple and complex mechanisms are involved. Better understanding of immunologic pathomechanisms in DHRs and rapid progress in cellular-based in-vitro tests can help to adjust the correct diagnostic strategy to individual patients with different clinical manifestations of drug allergy. Thus, drug hypersensitivity diagnosis needs to rely on a combination of medical history and different in vivo and in vitro tests. In this article, the authors discuss current in vitro techniques, most recent findings, and new promising tools in the diagnosis of T-cell-mediated drug hypersensitivity.
Author information
Author/s: Lochmatter, Priska (P); Zawodniak, Anna (A); Pichler, Werner J (WJ);
Affiliation: Division of Allergology, Clinic of Rheumatology and Clinical Immunology/Allergology, Inselspital, Bern University Hospital and University of Bern, Bern CH-3010, Switzerland.
Journal and publication information
Publication Type: Journal Article
Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am), published in United States. (Language: eng)
Reference: 2009-Aug; vol 29 (issue 3) : pp 537-54
Dates: Created 2009/06/30; Completed 2009/10/22;
PMID: 19563996, status: MEDLINE (last retrieval date: 10/22/2009, IMS Date: 22 Oct 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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