Research article summary (published 30 Jul 2009):

Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats.

Full Abstract

Rats exposed to single-prolonged stress (SPS) showed enhanced inhibition of the hypothalamic-pituitary-adrenal (HPA) system and alteration in the glucocorticoid/mineralocorticoid receptor. Dysfunction of the HPA axis is one of the core neuroendocrine abnormalities of post-traumatic stress disorder (PTSD). Serotonergic receptor, glucocorticoid receptor (GR) and corticotropin-releasing factor (CRF) have been proposed to play major roles in dysfunction of the HPA axis. However, the precise molecular mechanism is unknown. In this study, we investigated the relationships between the changes of GR in hippocampus as well as CRF in hypothalamus and the activity of 5-HT1A receptor in SPS rats. We exposed rats to SPS with or without prior treatment with WAY100635 (the 5-HT1A receptor antagonist), and observed behavioral changes, GR levels in the hippocampus and CRF levels in the hypothalamus by immunohistochemistry, Western blotting and RT-PCR seven days after SPS. Our results demonstrate that SPS increases expression of GR and CRF, which were partially inhibited by WAY-100635.

Author information

Author/s: Wang, Hai-Tao (HT); Han, Fang (F); Shi, Yu-Xiu (YX);

Affiliation: Department of Histology and Embryology, Basic Medical Sciences College, China Medical University, Shenyang 110001, Liaoning Province, PR China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International journal of molecular medicine (Int J Mol Med), published in Greece. (Language: eng)

Reference: 2009-Aug; vol 24 (issue 2) : pp 227-31

Dates: Created 2009/07/06; Completed 2009/09/24;

PMID: 19578795, status: MEDLINE (last retrieval date: 9/24/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Blotting, Western Corticotropin-Releasing Hormone - genetics; metabolism Gene Expression Hippocampus - drug effects; metabolism Hypothalamus - drug effects; metabolism Immunohistochemistry Male Maze Learning - physiology Piperazines - pharmacology

Pyridines - pharmacology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT1A - genetics; metabolism Receptors, Glucocorticoid - genetics; metabolism Restraint, Physical - adverse effects; psychology Reverse Transcriptase Polymerase Chain Reaction Serotonin Antagonists - pharmacology Stress, Psychological - etiology; physiopathology; prevention & control Swimming - psychology

Associated Chemicals: Piperazines (0) ; Pyridines (0) ; Receptors, Glucocorticoid (0) ; Serotonin Antagonists (0) ; Receptor, Serotonin, 5-HT1A (112692-38-3) ; WAY 100635 (146714-97-8) ; Corticotropin-Releasing Hormone (9015-71-8)

Related articles

These are the highest related articles currently in the database:

• Antagonist-induced increase in 5-HT1A-receptor expression in adult rat hippocampus and cortex. 29 Jun 2007
• Native rat hippocampal 5-HT1A receptors show constitutive activity. 11 Dec 2006
• Colocalization of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and hypothalamus. 18 Jan 2005
• Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. 10 Jun 2008
• Restraint-induced corticosterone secretion and hypothalamic CRH mRNA expression are augmented during acute withdrawal from chronic cocaine administration. 19 Jan 2007
• An estrogenic effect of 5alpha-androstane-3beta, 17beta-diol on the behavioral response to stress and on CRH regulation. 2 Apr 2008
• Effect of serotonin inhibition on glucocorticoid and mineralocorticoid expression in various brain structures. 30 Jan 1999
• Antisense oligonucleotides to corticotropin-releasing factor impair memory retention and increase exploration in rats. 29 Apr 1997
• The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis. 12 May 2004
• Melatonin effects on glucocorticoid receptors in rat brain and pituitary: significance in adrenocortical regulation. 30 Dec 1990

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.