Research article summary (published 13 Oct 2009):

Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients.

Full Abstract

Expression of caveolin-1 (Cav-1) and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) and their prognostic significance were analyzed in archive NPC samples. Cav-1 and CD147 were overexpressed in 49.48% (96/194) and 59.39% (117/197) of NPC, respectively. Both Cav-1 and CD147 expression levels correlated significantly with metastasis (p = 0.025 and 0.017, respectively) and a lower 5-year survival rate (p = 0.02 and 0.0009, respectively). In addition, Cav-1 expression levels correlated significantly with local recurrence (p = 0.038). Multivariate Cox regression analysis indicated that combination of high Cav-1 and CD147 expression was a significant, independent prognosis predictor in patients with NPC (HR = 2.135; p = 0.006). Functional studies revealed that overexpression of Cav-1 promoted secretion of MMP-3 and MMP-11 (active) proteins, as well as an increase in the migratory ability of CNE1 and CNE2 cells, while siRNA-mediated silencing of Cav-1 or CD147 led to reduced levels of MMP-3 and MMP-11(active) secretion, and reduced migration capacity of CNE1 and CNE2 cells. We observed a positive correlation between Cav-1 and CD147 expression in NPC (rho = 0.330, p = 0.000), CD147 protein levels were upregulated in Cav-1 overexpressing CNE1 and CNE2 cells, whereas siRNA-mediated silencing of Cav-1 led to the downregulation of CD147 expression. Our results indicate that Cav-1 and CD147 overexpression predict poor NPC prognosis and enhanced tumor cell migration, which is associated with MMP-3 and MMP-11 (active) secretion.

Author information

Author/s: Du, Zi-Ming (ZM); Hu, Chun-Fang (CF); Shao, Qiong (Q); Huang, Ma-Yan (MY); Kou, Chang-Wei (CW); Zhu, Xiao-Feng (XF); Zeng, Yi-Xin (YX); Shao, Jian-Yong (JY);

Affiliation: State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, People's Republic of China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2009-Oct; vol 125 (issue 8) : pp 1832-41

Dates: Created 2009/08/26; Completed 2009/09/21;

PMID: 19582878, status: MEDLINE (last retrieval date: 9/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Aged Aged, 80 and over Antigens, CD147 - genetics; metabolism Caveolin 1 - antagonists & inhibitors; genetics; metabolism Cell Movement Female Humans Immunoblotting Immunoenzyme Techniques Lymphatic Metastasis Male Matrix Metalloproteinase 11 - metabolism

Matrix Metalloproteinase 3 - metabolism Middle Aged Nasopharyngeal Neoplasms - metabolism; pathology Neoplasm Invasiveness Neoplasm Recurrence, Local - metabolism; pathology Neoplasm Staging Prognosis RNA, Messenger - genetics; metabolism Reverse Transcriptase Polymerase Chain Reaction Survival Rate Tissue Array Analysis Tumor Cells, Cultured Up-Regulation - physiology Young Adult

Associated Chemicals: BSG protein, human (0) ; CAV1 protein, human (0) ; Caveolin 1 (0) ; RNA, Messenger (0) ; Antigens, CD147 (136894-56-9) ; Matrix Metalloproteinase 11 (EC 3.4.24.-) ; Matrix Metalloproteinase 3 (EC 3.4.24.17)

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