Research article summary (published 30 May 2009):

Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice.

Full Abstract

Matrix metalloproteinase-8 (MMP-8) participates in skin wound healing and inflammation. We hypothesized that MMP-8 plays a role in wound healing after tooth extraction and in periapical inflammation. Bone formation, collagen metabolism, and inflammation in tooth extraction socket and in periapical lesions were analyzed in wild-type mice and in MMP-8-deficient (MMP-8(-/-)) mice. New trabecular bone area in the extraction sockets and in periapical lesions were similar in both groups. In extraction sockets significantly more type III procollagen was synthesized, and the neutrophil and MMP-9 levels were lower in MMP-8(-/-) mice. The amount of Fas ligand, identified as a substrate for MMP-8, was lower in alveolar mucosa but higher in alveolar bone of MMP-8(-/-) mice. These results indicate that MMP-8 can modulate inflammation and collagen metabolism of alveolar bone and mucosa.

Author information

Author/s: Korpi, Jarkko T (JT); Aström, Pirjo (P); Lehtonen, Niko (N); Tjäderhane, Leo (L); Kallio-Pulkkinen, Soili (S); Siponen, Maria (M); Sorsa, Timo (T); Pirilä, Emma (E); Salo, Tuula (T);

Affiliation: Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Oulu and Oulu University Hospital, Oulu, Finland.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: European journal of oral sciences (Eur J Oral Sci), published in Denmark. (Language: eng)

Reference: 2009-Jun; vol 117 (issue 3) : pp 248-54

Dates: Created 2009/07/08; Completed 2009/10/29;

PMID: 19583751, status: MEDLINE (last retrieval date: 10/29/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alveolar Process - enzymology Animals Chemokine CX3CL1 - analysis Collagen - metabolism Collagen Type III - biosynthesis Fas Ligand Protein - analysis Granulocyte Colony-Stimulating Factor - analysis Granulocyte-Macrophage Colony-Stimulating Factor - analysis Interferon-gamma - analysis Interleukin-6 - analysis Leukocyte Count Male Matrix Metalloproteinase 8 - deficiency

Matrix Metalloproteinase 9 - analysis Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Knockout Mouth Mucosa - enzymology Neutrophils - enzymology; pathology Osteogenesis - physiology Periapical Diseases - enzymology; physiopathology Procollagen - biosynthesis Tooth Extraction Tooth Socket - enzymology; physiopathology Wound Healing - physiology

Associated Chemicals: Chemokine CX3CL1 (0) ; Collagen Type III (0) ; Fas Ligand Protein (0) ; Interleukin-6 (0) ; Procollagen (0) ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Interferon-gamma (82115-62-6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) ; Collagen (9007-34-5) ; Mmp9 protein, mouse (EC 3.4.24.-) ; Matrix Metalloproteinase 8 (EC 3.4.24.34) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)

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