Post-transplant EBV-related lymphoproliferative disorder complicating umbilical cord blood transplantation in patients of adrenoleukodystrophy.

Full Abstract

EBV-associated post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) using bone marrow or peripheral blood as stem cell sources, but rarely reported in umbilical cord blood transplantation (UCBT). We report two cases in unrelated UCBT setting and added the following new information to the literature: (i) EBV-related PTLD can be presented late in recipients of unrelated UCBT; (ii) in contrast to reported literatures that PTLD is a serious complication with unfavorable outcome, especially in monomorphic form, our cases showed that the clinical course may be relatively benign if treatment is initiated promptly. (c) 2009 Wiley-Liss, Inc.

Author information

Author/s: Cheng, Frankie Wai Tsoi (FW); Lee, Vincent (V); To, Ka Fai (KF); Chan, K C Allen (KC); Shing, Ming Kong (MK); Li, Chi Kong (CK);

Affiliation: Department of Pediatrics, Lady Pao Children's Cancer Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. frankiecheng(-atsign-)cuhk.edu.hk

Journal and publication information

Publication Type: Case Reports; Journal Article

Journal: Pediatric blood & cancer (Pediatr Blood Cancer), published in United States. (Language: eng)

Reference: 2009-Dec; vol 53 (issue 7) : pp 1329-31

Dates: Created 2009/10/19; Completed 2009/11/17;

PMID: 19591223, status: MEDLINE (last retrieved date: 11/17/2009)

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Herpesvirus 4, Human - physiology
Humans
Immunoglobulins, Intravenous - therapeutic use
Immunologic Factors - therapeutic use
Immunosuppressive Agents - adverse effects; therapeutic use
Lymphoproliferative Disorders - drug therapy; etiology; therapy; virology
Male
Postoperative Complications - drug therapy; etiology; therapy; virology
Prednisolone - administration & dosage; adverse effects; therapeutic use
Remission Induction
Tumor Virus Infections - complications; drug therapy
Virus Activation - drug effects

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Antibodies, Monoclonal (0) ; Antiviral Agents (0) ; Immunoglobulins, Intravenous (0) ; Immunologic Factors (0) ; Immunosuppressive Agents (0) ; rituximab (0) ; Prednisolone (50-24-8) ; Acyclovir (59277-89-3) ; Cyclosporine (59865-13-3)

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