Research article summary (published 8 Jul 2009):

The Mycobacterium tuberculosis sigma factor sigmaB is required for full response to cell envelope stress and hypoxia in vitro, but it is dispensable for in vivo growth.

Full Abstract

The numerous sigma (sigma) factors present in Mycobacterium tuberculosis are indicative of the adaptability of this pathogen to different environmental conditions. In this report, we describe the M. tuberculosis sigma(B) regulon and the phenotypes of an M. tuberculosis sigB mutant strain exposed to cell envelope stress, oxidative stress, and hypoxia. The sigB mutant was especially defective in survival under hypoxic conditions in vitro, but it was not attenuated for growth in THP-1 cells or during mouse and guinea pig infection.

Author information

Author/s: Fontán, P A (PA); Voskuil, M I (MI); Gomez, M (M); Tan, D (D); Pardini, M (M); Manganelli, R (R); Fattorini, L (L); Schoolnik, G K (GK); Smith, I (I);

Affiliation: PHRI Center of NJMS-UMDNJ, 225 Warren Street, Newark, New Jersey 07103-3535, USA.

Grants: AI-061505 (Agency:NIAID NIH HHS) ; N01-A/30036 (Agency:PHS HHS) ; R01 AI-44856 (Agency:NIAID NIH HHS) ; R01 AI44826 (Agency:NIAID NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of bacteriology (J Bacteriol), published in United States. (Language: eng)

Reference: 2009-Sep; vol 191 (issue 18) : pp 5628-33

Dates: Created 2009/08/28; Completed 2009/09/17;

PMID: 19592585, status: MEDLINE (last retrieved date: 9/17/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Anoxia Bacterial Proteins - genetics; metabolism Cell Wall - metabolism Cells, Cultured Gene Expression Profiling Gene Expression Regulation, Bacterial Guinea Pigs Heat-Shock Response Humans

Macrophages - microbiology Mice Mice, Inbred BALB C Mutation Mycobacterium tuberculosis - genetics; growth & development; pathogenicity; physiology Oligonucleotide Array Sequence Analysis Oxidative Stress Regulon Sigma Factor - genetics; metabolism Tuberculosis, Pulmonary - microbiology; pathology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Bacterial Proteins (0) ; SigB protein, Bacteria (0) ; Sigma Factor (0)

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